1.
AIDS
; 16(12): 1684-6, 2002 Aug 16.
Article
in English
| MEDLINE
| ID: mdl-12172092
ABSTRACT
In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.