ABSTRACT
Recent legislative developments have led to a marked increase in the empirical investigation of motivations and judgments of so-called acts of "revenge pornography" offending. In two independently sampled studies, we used moderation analyses to investigate whether higher levels of intrasexual competition predicted more lenient judgments of revenge pornography offenses as a function of sex (Study 1, N = 241), and whether such relationships would be further moderated by physical attractiveness (Study 2, N = 402). Potential covariates of callous-unemotional traits, empathy, and victimization history were controlled for. Opposing our hypotheses, we consistently observed a trend for higher levels of intrasexual competition being associated with more lenient judgments of revenge pornography offenses involving male victims by female participants. The results are discussed in terms of intrasexual competition potentially sharing variance with unobserved constructs in the wider sexological literature, and of the key relevance of these findings for future empirical investigation into judgments of nonconsensual image-based offending.
Subject(s)
Criminals/psychology , Erotica/psychology , Sex Offenses/psychology , Adult , Conduct Disorder , Crime Victims , Effect Modifier, Epidemiologic , Empathy , Erotica/legislation & jurisprudence , Female , Humans , Judgment , Male , Middle Aged , Physical Appearance, Body , Reproducibility of Results , Sex Offenses/legislation & jurisprudence , United KingdomABSTRACT
Aims: Heart failure (HF) is a pro-thrombotic state. Both platelet and vascular responses to nitric oxide (NO) donors are impaired in HF patients with reduced ejection fraction (HFrEF) compared with healthy volunteers (HVs) due to scavenging of NO, and possibly also reduced activity of the principal NO sensor, soluble guanylate cyclase (sGC), limiting the therapeutic potential of NO donors as anti-aggregatory agents. Previous studies have shown that nitrite inhibits platelet activation presumptively after its reduction to NO, but the mechanism(s) involved remain poorly characterized. Our aim was to compare the effects of nitrite on platelet function in HV vs. HF patients with preserved ejection fraction (HFpEF) and chronic atrial fibrillation (HFpEF-AF), vs. patients with chronic AF without HF, and to assess whether these effects occur independent of the interaction with other formed elements of blood. Methods and results: Platelet responses to nitrite and the NO donor sodium nitroprusside (SNP) were compared in age-matched HV controls (n = 12), HFpEF-AF patients (n = 29), and chronic AF patients (n = 8). Anti-aggregatory effects of nitrite in the presence of NO scavengers/sGC inhibitor were determined and vasodilator-stimulated phosphoprotein (VASP) phosphorylation was assessed using western blotting. In HV and chronic AF, both nitrite and SNP inhibited platelet aggregation in a concentration-dependent manner. Inhibition of platelet aggregation by the NO donor SNP was impaired in HFpEF-AF patients compared with healthy and chronic AF individuals, but there was no impairment of the anti-aggregatory effects of nitrite. Nitrite circumvented platelet NO resistance independently of other blood cells by directly activating sGC and phosphorylating VASP. Conclusion: We here show for the first time that HFpEF-AF (but not chronic AF without HF) is associated with marked impairment of platelet NO responses due to sGC dysfunction and nitrite circumvents the 'platelet NO resistance' phenomenon in human HFpEF, at least partly, by acting as a direct sGC activator independent of NO.
