1.
J Pharm Pharmacol
; 36(5): 295-9, 1984 May.
Article
in English
| MEDLINE
| ID: mdl-6145763
ABSTRACT
An in-vitro test system was developed to investigate the adhesiveness of various materials to mucus. The results obtained showed good agreement with the findings of previous in-vivo evaluations of mucosa-adhesives. Further investigations found that these materials become adhesive on hydration. Chain length, and the presence of ionizable groups in the molecule, were found to be determinate factors. The physical nature of the gel, and the location at which the mucoadhesive materials hydrated, were of less importance.
Subject(s)
Mucous Membrane/physiology , Pharmaceutical Preparations/administration & dosage , Pharmaceutical Vehicles , Adhesiveness , Animals , Chemical Phenomena , Chemistry, Physical , Gels , Guinea Pigs , In Vitro Techniques , Intestinal Mucosa/physiology , Models, Biological , Molecular Weight , Rheology , Surface Tension , Time Factors
2.
J Pharm Pharmacol
; 26 Suppl: 76P, 1974 Dec.
Article
in English
| MEDLINE
| ID: mdl-4156757
3.
J Pharm Pharmacol
; 25(8): 679-80, 1973 Aug.
Article
in English
| MEDLINE
| ID: mdl-4148449
4.
Acta Derm Venereol Suppl (Stockh)
; 53: 29-34, 1973.
Article
in English
| MEDLINE
| ID: mdl-4518660
Subject(s)
Anti-Inflammatory Agents/administration & dosage , Pregnadienediols/administration & dosage , Skin Absorption , Administration, Topical , Dermatologic Agents , Dosage Forms , Drug Evaluation , Drug Stability , Emulsions , Glucocorticoids , Humans , Ketosteroids/administration & dosage , Ointments , Particle Size , Pharmaceutic Aids , Pharmaceutical Vehicles , Solubility , Solutions , Steroids, Chlorinated/administration & dosage , Steroids, Fluorinated/administration & dosage , Surface-Active Agents , Viscosity
5.
J Pharm Pharmacol
; 23: 101S-110S, 1971 Dec.
Article
in English
| MEDLINE
| ID: mdl-4401443
Subject(s)
Crystallization , Sulfadiazine , Chemical Engineering , Dimethylformamide , Dosage Forms , Powders
6.
J Pharm Pharmacol
; 20(11): 830-5, 1968 Nov.
Article
in English
| MEDLINE
| ID: mdl-4387488
