ABSTRACT
The study material comprised 31 patients with chronic suppurative infections of the skin caused by Pseudomonas, Staphylococcus, Klebsiella, Proteus and Escherichia. Within 2-16 weeks of the treatment, an improvement of the general state was observed as well as suppression of the local inflammation, purification of a wound from the suppurative and necrotic content, faster healing of the ulcers and fully negative results of the bacteriologic tests. In 16 cases, an outstanding therapeutic effect was obtained, in 7 cases marked improvement was reported and in 2 a transitory improvement was reported. In 7 patients the treatment was abandoned due to the lack of improvement (1 case) or development of side effects (6 cases). The results obtained provide evidence for the high effectiveness of phage therapy in the treatment of suppurative skin infections.
Subject(s)
Bacterial Infections/therapy , Bacteriophages , Skin Diseases, Infectious/therapy , Adolescent , Adult , Aged , Aged, 80 and over , Bacterial Infections/microbiology , Bacterial Infections/pathology , Child , Female , Humans , Male , Middle Aged , Skin Diseases, Infectious/microbiology , Skin Diseases, Infectious/pathologySubject(s)
Dermatology/history , Models, Anatomic , Dermatology/education , Germany , History, 19th Century , History, 20th Century , PolandABSTRACT
A newly synthetized compound, p-chlorophenylamide of 3-methyl-5-benzoylaminoisothiazole-4-carboxylic acid (ITCL) was used for local treatment in 68 patients with the following skin diseases: herpes simplex, herpes zoster, eczema complicated by bacterial infection, aphthae of the mucosa. In all cases examined, a good tolerance of the drug, rapid subsidence of pathologic symptoms, mainly of inflammation, pain and edema could be seen. The drug was found to reduce markedly the duration of the disease, particularly in the case of herpes simplex and aphthae.
Subject(s)
Anti-Infective Agents/therapeutic use , Antiviral Agents/therapeutic use , Skin Diseases, Infectious/drug therapy , Skin Diseases/drug therapy , Thiazoles/pharmacology , Adolescent , Adult , Aged , Child , Eczema/drug therapy , Female , Herpes Simplex/drug therapy , Herpes Zoster/drug therapy , Humans , Impetigo/drug therapy , Male , Middle Aged , Ointments , Stomatitis, Aphthous/drug therapySubject(s)
Epoxy Resins/toxicity , Skin/immunology , Female , Hardness , Humans , Immunization , Male , Patch TestsABSTRACT
In women employed in an industrial plant in direct contact with epoxide resins and their hardeners, the following biochemical parameters were determined in blood: total protein, seromucoid, haptoglobin, hemoglobin variants, methemoglobin, alpha1-inhibitor of trypsin, lactate dehydrogenase, aspartate and alanine aminotransferases, alkaline and acid phosphatase, gamma-glutamyl transpeptidase, leucylaminopeptidase, and alanine aminopeptidase. Depending on duration of work, Hb A2 fraction and lactate dehydrogenase increased significantly, and aspartate aminotransferase, acid and alkaline phosphatase activities decreased. In pregnant women, leucylaminopeptidase activity and isozyme of placental alkaline phosphatase were decreased.
Subject(s)
Blood Chemical Analysis , Epoxy Resins/adverse effects , Acid Phosphatase/blood , Alkaline Phosphatase/blood , Aspartate Aminotransferases/blood , Female , Haptoglobins/analysis , Hemoglobin A/analysis , Humans , L-Lactate Dehydrogenase/blood , Methemoglobin/analysis , Pregnancy , Time FactorsABSTRACT
Skin tests of hypersensitivity were performed in 175 women and 16 men having direct contact during work with epoxide resinsand their hardeners. The tests were applied for 24 hours, and results were recorded after 24, 48 and 72 hours. The percentages of positive skin tests and numbers of skin lesions were found to increase with time of employment in contact with epoxide resins and their hardeners.
Subject(s)
Anhydrides/immunology , Dermatitis, Contact/etiology , Dermatitis, Occupational/chemically induced , Epoxy Resins/adverse effects , Amines/immunology , Eczema/chemically induced , Eczema/immunology , Ethanolamines/immunology , Eyelid Diseases/chemically induced , Female , Fingers , Forearm , Humans , Male , Skin TestsSubject(s)
Epoxy Resins/pharmacology , Ethylenediamines/pharmacology , Acetylcholinesterase/metabolism , Alanine Transaminase/metabolism , Animals , Aspartate Aminotransferases/metabolism , Brain/drug effects , Brain/enzymology , Female , Kidney/drug effects , Kidney/enzymology , Liver/drug effects , Liver/enzymology , Pregnancy , Rats , gamma-Glutamyltransferase/metabolismSubject(s)
Breast Neoplasms/diagnosis , Ovarian Neoplasms/diagnosis , Skin Neoplasms/diagnosis , Stomach Neoplasms/diagnosis , Adult , Aged , Female , Humans , Male , Middle Aged , Neoplasm MetastasisSubject(s)
Dermatitis, Atopic/immunology , Lymphocyte Activation , Adult , Antibody Formation , Female , Humans , Lectins , Male , Middle Aged , Remission, SpontaneousSubject(s)
Epoxy Resins/adverse effects , Pregnancy/drug effects , Administration, Topical , Animals , Epoxy Resins/administration & dosage , Fatty Liver/chemically induced , Female , Fetal Death/chemically induced , Guinea Pigs , Hyperemia/chemically induced , Kidney Diseases/chemically induced , Maternal Mortality , Maternal-Fetal Exchange , Placenta/drug effects , Skin/drug effects , Time FactorsABSTRACT
Gamma-glutamyl transpeptidase activity in kidney homogenates, aspartate and alanine aminotransferase activities in liver homogenates, and cholinesterase activity in brain homogenates were determined in nonpregnant and pregnant guinea pigs exposed to absorption through the skin of the epoxy resin triethylenetetramine. Elevated activity of gamma-glutamyl transpeptidase in the kidneys of pregnant animals, and aspartate aminotransferase in the liver of nonpregnant guinea pigs were observed.
