ABSTRACT
During 10 minutes of infusion of noradrenaline in doses of 0.1, 0.2, 0.4 and 0.6 micrograms/min into isolated intestinal, kidney and hindquartet preparation, perfused with aerated Tyrode's solution and escape effect was observed in normotensive rats. The escape was significantly reduced in intestinal and renal vascular beds or disappeared in spontaneously hypertensive rats.
Subject(s)
Hypertension/physiopathology , Kidney/blood supply , Norepinephrine/pharmacology , Splanchnic Circulation , Vasomotor System/physiopathology , Animals , Extremities/blood supply , Intestines/blood supply , Rats , Rats, Inbred SHRSubject(s)
Heart/physiology , Hemodynamics , Pregnancy , Echocardiography , Female , Humans , Pregnancy Trimester, Second , Pregnancy Trimester, ThirdSubject(s)
Fatty Acids/blood , Hyperthyroidism/blood , Female , Humans , Linoleic Acids/deficiency , Linolenic Acids/deficiency , MaleSubject(s)
Heart/physiopathology , Hyperthyroidism/physiopathology , Adult , Cardiac Output , Female , Humans , Male , SystoleABSTRACT
The noradrenaline, adrenaline and acetylcholine-induced vasoregulatory escape was demonstrated in the vascular bed of intact of skinned and denervated dog's hind limb. Escape effect disappeared or decreased markedly under elevation tissue pressure in the examined hind limb. These data indicate that tissue pressure factor may take part in the mechanism of the escape phenomenon.
