ABSTRACT
INTRODUCTION: A case series of acute intermittent porphyria (AIP) is described that focuses on the clinical course of the disease with regard to neurological manifestations of the peripheral nervous system. METHODS: Eight patients were diagnosed with AIP on the basis of characteristic clinical findings, erythrocyte porphobilinogendeaminase activity, neuropathic patterns, serial changes in nerve conduction studies (NCS), and temporal relationship of central nervous system involvement. RESULTS: Six patients diagnosed with AIP<2 months after symptom onset had neuropathy that was predominantly upper extremity, motor, and proximal. NCS recovery rates were slower in the lower than the upper limbs. Two patients diagnosed >2 months after symptom onset had distal sensorimotor polyneuropathy. CONCLUSIONS: The findings from this case series suggest that the peripheral nerves may be differentially and selectively involved in different diagnostic stages of porphyric neuropathy.
Subject(s)
Electromyography , Neural Conduction/physiology , Polyneuropathies/diagnosis , Polyneuropathies/physiopathology , Porphyria, Acute Intermittent/diagnosis , Porphyria, Acute Intermittent/physiopathology , Adult , Electromyography/methods , Electrophysiological Phenomena/physiology , Female , Follow-Up Studies , Humans , Male , Retrospective Studies , Young AdultABSTRACT
The rapid development of wireless broadband communication technology has affected the location accuracy of worldwide radio monitoring stations that employ time-difference-of-arrival (TDOA) location technology. In this study, TDOA-based location technology was implemented in Taiwan for the first time according to International Telecommunications Union Radiocommunication (ITU-R) recommendations regarding monitoring and location applications. To improve location accuracy, various scenarios, such as a three-dimensional environment (considering an unequal locating antenna configuration), were investigated. Subsequently, the proposed integrated cross-correlation and genetic algorithm was evaluated in the metropolitan area of Tainan. The results indicated that the location accuracy at a circular error probability of 50% was less than 60 m when a multipath effect was present in the area. Moreover, compared with hyperbolic algorithms that have been applied in conventional TDOA-based location systems, the proposed algorithm yielded 17-fold and 19-fold improvements in the mean difference when the location position of the interference station was favorable and unfavorable, respectively. Hence, the various forms of radio interference, such as low transmission power, burst and weak signals, and metropolitan interference, was proved to be easily identified, located, and removed.
Subject(s)
Algorithms , Radio Waves , Telecommunications , Computer Simulation , Humans , Taiwan , Time Factors , User-Computer InterfaceABSTRACT
BACKGROUND: Acute intermittent porphyria (AIP) is an inherited disorder of heme biosynthesis, the clinical manifestations of which are incompletely understood. In this report, we describe 12 cases of AIP, focusing on the neurological manifestations. METHODS: Twelve patients were diagnosed with AIP on the basis of characteristic clinical findings, erythrocyte porphobilinogen deaminase (PBGD) activity, and molecular genetics. Central and peripheral nervous system manifestations were noted, and electrophysiological and radiological studies performed. Potential precipitating factors were recorded. RESULTS: Eleven PBGD gene mutations were identified in 12 patients. Nine patients experienced neurological symptoms involving the central nervous system (consciousness disturbance, n = 8; convulsion/seizure, n = 4; behavior change, n = 1), while 7 patients experienced peripheral neuropathies (motor paresis, n = 7; impairment of bulbar or respiratory function, n = 4). The electrophysiological and electroencephalographic findings were consistent with the neurological symptoms of AIP. Urinary PBG and δ-aminolevulinic acid levels were elevated in all patients. PBGD enzyme activity levels were below normal in all patients. Eight patients had documented exposure to porphyrogenic agents. CONCLUSIONS: Our detailed description of a relatively large number of cases of AIP may help clinicians to recognize this often difficult-to-diagnose disorder.
Subject(s)
Nervous System Diseases/etiology , Porphyria, Acute Intermittent/complications , Adolescent , Adult , Aminolevulinic Acid/urine , Brain/diagnostic imaging , Brain/pathology , Electroencephalography/methods , Electromyography , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Nervous System Diseases/diagnosis , Neural Conduction/physiology , Porphobilinogen/urine , Porphyria, Acute Intermittent/urine , Retrospective Studies , Tomography, X-Ray Computed , Young AdultABSTRACT
An autostereoscopic display with parallax barrier attached onto a liquid crystal panel suffers from the trade-off between brightness and crosstalk. One approach for making improvement by modifying the layout of light blocking components, such as thin film transistor, storage capacitor, and protrusion, in the liquid crystal pixel has been proposed. Ray tracing simulation shows that the aperture of the slanted barrier can be significantly increased, hence increasing efficiency, while keeping the same crosstalk level if those light blocking components can be shifted to the corner of the pixel. A six-view 2.83 in. (7.19 cm) prototype has shown improvement on both brightness and crosstalk compared to its counterpart using a traditional liquid crystal panel, which demonstrates an effective approach for a high-efficiency barrier-type autostereoscopic 3D display with a liquid crystal panel.
Subject(s)
Computer Graphics/instrumentation , Computer Terminals , Data Display , Imaging, Three-Dimensional/instrumentation , Lighting/instrumentation , Liquid Crystals/chemistry , Signal Processing, Computer-Assisted/instrumentation , Computer-Aided Design , Equipment Design , Equipment Failure Analysis , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
Resistance to conventional fungicides causes the poor disease control of agriculture. Natural products from plants have great potential as novel fungicide sources for controlling pathogenic fungi. In this study antipathogenic activity of the leaf essential oil and its constituents from Calocedrus macrolepis var. formosana Florin were evaluated in vitro against six plant pathogenic fungi. Chemical analysis of leaf oil by GC/MS allowed identification of alpha-pinene (44.2%), limonene (21.6%), beta-myrcene (8.9%), beta-caryophyllene (8.2%), caryophyllene oxide (2.4%), alpha-cadinol (1.6%), beta-pinene (1.2%), and T-muurolol (1.1%) as main components. Sesquiterpenoid components of the oil were more effective than monoterpenoid components of the oil. In particular, T-muurolol and alpha-cadinol strongly inhibited the growth of Rhizoctonia solani and Fusarium oxysporum, with the IC(50) values < 50 microg ml(-1). These compounds also efficiently inhibited the mycelial growths of Colletotrichum gloeosporioides, P. funerea, Ganoderma australe and F. solani. These results showed that T-muurolol and alpha-cadinol possess antifungal activities against a broad spectrum of tested plant pathogenic fungi and could be used as potential antifungal agents for the control of fungal diseases in plants.
Subject(s)
Antifungal Agents/pharmacology , Cupressaceae/chemistry , Oils, Volatile/pharmacology , Plant Leaves/chemistry , Cupressaceae/microbiology , Fungi/pathogenicity , Gas Chromatography-Mass Spectrometry , Oils, Volatile/isolation & purification , Plant Diseases/microbiology , Plant Leaves/microbiologyABSTRACT
In this study, the anti-termitic activities of 11 essential oils from three species of coniferous tree against Coptotermes formosanus Shiraki were investigated using direct contact application. Results demonstrated that at the dosage of 10 mg/g, the heartwood and sapwood essential oils of Calocedrus macrolepis var. formosana and Cryptomeria japonica and the leaf essential oil of Chamaecyparis obtusa var. formosana had 100% mortality after 5 d of test. Among the tested essential oils, the heartwood essential oil of C. macrolepis var. formosana killed all termites after 1 d of test, with an LC(50) value of 2.6 mg/g, exhibiting the strongest termiticidal property. The termiticidal effect of heartwood essential oil was due to its toxicity and its repellent action.
Subject(s)
Chamaecyparis/chemistry , Cryptomeria/chemistry , Isoptera/drug effects , Plant Oils/pharmacology , Animals , Dose-Response Relationship, Drug , Insecticides/chemistry , Insecticides/pharmacology , Plant Oils/chemistry , Time Factors , Wood/chemistryABSTRACT
Calocedrus formosana Florin (Cupressaceae) is an endemic tree species in Taiwan; its timber is recognized for natural decay resistance. To examine the antitermitic and antifungal activities of leaf essential oil and its main constituents, C. formosana leaves were extracted and the essential oils analyzed by GC-MS. Bioactivity tests against the termite Coptotermes formosanus demonstrate that the LC50 value of leaf essential oil is 27.6 mg/g. Furthermore, exposure to T-muurolol caused 100% mortality at a dosage of 5 mg/g after 14 d. Leaf oil constituents displayed activity against four fungi, Lenzites betulina, Pycnoporus coccineus, Trametes versicolor, and Laetiporus sulphureus. Two compounds, alpha-cadinol and T-muurolol, exhibited the strongest antifungal activity. The LC50 values of alpha-cadinol against L. sulphureus, L. betulina, and T. versicolor are 9.9, 28.6, and 30.4 microg/ml, respectively.