ABSTRACT
Implant infections frequently occur in various kinds of surgery. Apart from antibiotics, the surface modification of implant material is a promising avenue to resolve this global problem. An ideal implant interface is expected to possess good biocompatibility, as well as broad-spectrum and long-term bacterial inhibition capabilities. Here, a delicate cicada and catkin inspired dual biomimetic structure was proposed, for the first time, to improve the antibacterial properties of implant material. By using poly(ether-ether-ketone) (PEEK) as a model implant, the relative in vitro and in vivo evaluations demonstrated that this dual biomimetic structure could simultaneously provide less bacterial adhesion, wider antimicrobial range and longer antibacterial durability. Meanwhile, the modified implant also retained ideal biocompatibility. Most importantly, the relative dual biomimetic structure engineering process could be accomplished through a simple, economic and fast hydrothermal chemical reaction, which might have an impact on the development of future biomedical materials.
Subject(s)
Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Biomimetic Materials/chemistry , Biomimetic Materials/pharmacology , Flowers , Hemiptera , 3T3 Cells , Animals , Anti-Bacterial Agents/toxicity , Bacterial Adhesion/drug effects , Benzophenones , Biomimetic Materials/toxicity , Hemolysis/drug effects , Ketones/chemistry , Male , Mice , Nanostructures/chemistry , Polyethylene Glycols/chemistry , Polymers , Prostheses and Implants , Rabbits , Rats , Staphylococcus aureus/drug effects , Surface Properties , Zinc Oxide/chemistryABSTRACT
The application of polydopamine (PDA)-modified titanium dioxide nanoparticles (nano-TiO2@PDA) as a new blue-light-activated tooth whitening material was discussed for the first time. Compared with the classical clinical whitening agent (peroxide, hydrogen peroxide, and carbamide peroxide), nano-TiO2@PDA-based treatment not only had a similar whitening effect but also showed remarkably less damage on the enamel structure. Essentially, a highly effective and nondestructive tooth whitening treatment could thus be realized accordingly. The toxicity and antibacterial properties of this material were also evaluated systematically.
