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Int J Mol Sci ; 16(9): 21950-8, 2015 Sep 11.
Article in English | MEDLINE | ID: mdl-26378524

ABSTRACT

Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 µM).


Subject(s)
Porifera/chemistry , Sesterterpenes/chemistry , Sesterterpenes/toxicity , Animals , Cell Line , Cell Proliferation/drug effects , Humans , Molecular Structure
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