Using machine learning to understand the temporal morphology of the PM2.5 annual cycle in East Asia.

PM2.5 air pollution is a significant issue for human health all over the world, especially in East Asia. A large number of ground-based measurement sites have been established over the last decade to monitor real-time PM2.5 concentration. However, even this enhanced observational network leaves many gaps in characterizing the PM2.5 spatial distribution. Machine learning provides a variety of algorithms to help deal with these large spatial gaps-combining both remotely sensed and in situ observation data to estimate the global PM2.5 concentration. This study used a PM2.5 data product of six regions from the results of an unsupervised self-organizing map (SOM) with optimized ensemble learning approaches to highlight the most important meteorological and surface variables associated with PM2.5 concentration. These variables were then examined via multiple linear regression models to provide physical mechanistic insights into the morphology of the PM2.5 annual cycles.

Applying machine learning to forecast daily Ambrosia pollen using environmental and NEXRAD parameters.

Approximately 50 million Americans have allergic diseases. Airborne plant pollen is a significant trigger for several of these allergic diseases. Ambrosia (ragweed) is known for its abundant production of pollen and its potent allergic effect in North America. Hence, estimating and predicting the daily atmospheric concentration of pollen (ragweed pollen in particular) is useful for both people with allergies and for the health professionals who care for them. In this study, we show that a suite of variables including meteorological and land surface parameters, as well as next-generation radar (NEXRAD) measurements together with machine learning can be used to estimate successfully the daily pollen concentration. The supervised machine learning approaches we used included random forests, neural networks, and support vector machines. The performance of the training is independently validated using 10% of the data partitioned using the holdout cross-validation method from the original dataset. The random forests (R= 0.61, R2= 0.37), support vector machines (R= 0.51, R2= 0.26), and neural networks (R= 0.46, R2= 0.21) effectively predicted the daily Ambrosia pollen, where the correlation coefficient (R) and R-squared (R2) values are given in brackets. Three independent approaches-the random forests, correlation coefficients, and interaction information-were employed to rank the relative importance of the available predictors.

Estimating the daily pollen concentration in the atmosphere using machine learning and NEXRAD weather radar data.

Millions of people have an allergic reaction to pollen. The impact of pollen allergies is on the rise due to increased pollen levels caused by global warming and the spread of highly invasive weeds. The production, release, and dispersal of pollen depend on the ambient weather conditions. The temperature, rainfall, humidity, cloud cover, and wind are known to affect the amount of pollen in the atmosphere. In the past, various regression techniques have been applied to estimate and forecast the daily pollen concentration in the atmosphere based on the weather conditions. In this research, machine learning methods were applied to the Next Generation Weather Radar (NEXRAD) data to estimate the daily Ambrosia pollen over a 300 km × 300 km region centered on a NEXRAD weather radar. The Neural Network and Random Forest machine learning methods have been employed to develop separate models to estimate Ambrosia pollen over the region. A feasible way of estimating the daily pollen concentration using only the NEXRAD radar data and machine learning methods would lay the foundation to forecast daily pollen at a fine spatial resolution nationally.

Using machine learning to estimate atmospheric Ambrosia pollen concentrations in Tulsa, OK.

This article describes an example of using machine learning to estimate the abundance of airborne Ambrosia pollen for Tulsa, OK. Twenty-seven years of historical pollen observations were used. These pollen observations were combined with machine learning and a very complete meteorological and land surface context of 85 variables to estimate the daily Ambrosia abundance. The machine learning algorithms employed were Least Absolute Shrinkage and Selection Operator (LASSO), neural networks, and random forests. The best performance was obtained using random forests. The physical insights provided by the random forest are also discussed.

Insights Into the Morphology of the East Asia PM2.5 Annual Cycle Provided by Machine Learning.

The abundance of airborne particulate matter with an aerodynamic equivalent diameter of 2.5 µm or less (PM2.5) is a significant environmental and health issue. Many tools have been used to examine the relationship between PM2.5 abundance and meteorological variables, but some of the relationships are nonlinear, non-Gaussian, and even unknown. Machine learning provides a broad range of practical algorithms to help examine this issue. In this study, we use machine learning to classify the morphology of PM2.5 seasonal cycles in East Asia. Machine learning is able to objectively classify the seasonal cycles and, without a priori assumption, is able to clearly distinguish between urban and rural areas. We show an example of this in the Sichuan Basin of China. Furthermore, machine learning is also able to provide physical insights by identifying the key factors associated with each distinct shape of the seasonal cycle, such as highlighting the key role played by the topography and the built environment.

Lambda-cyhalothrin disrupts the up-regulation effect of 17ß-estradiol on post-synaptic density 95 protein expression via estrogen receptor α-dependent Akt pathway.

Lambda-cyhalothrin (LCT), one of the type II pyrethroids, has been widely used throughout the world. The estrogenic effect of LCT to increase cell proliferation has been well established. However, whether the estrogenic effect of LCT will influence neurodevelopment has not been investigated. In addition, 17ß-Estradiol (E2) plays a crucial role in neurodevelopment and induces an increase in synaptic proteins. The post-synaptic density 95 (PSD95) protein, which is involved in the development of the structure and function of new spines and localized with estrogen receptor α (ERα) at the post-synaptic density (PSD), was detected in our study by using hippocampal neuron cell line HT22. We found that LCT up-regulated PSD95 and ERα expression, estrogen receptor (ER) antagonist ICI182,780 and phosphatidylinositol-4; 5-bisphosphate 3-kinase (PI3K) inhibitor LY294,002 blocked this effect. In addition, LCT disrupted the promotion effect of E2 on PSD95. To investigate whether the observed changes are caused by ERα-dependent signaling activation, we next detected the effects of LCT on the ERα-mediated PI3K-Protein kinase B (PKB/Akt)-eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) pathway. There existed an activation of Akt and the downstream factor 4E-BP1 after LCT treatment. In addition, LCT could disrupt the activation effect of E2 on the Akt pathway. However, no changes in cAMP response element-binding protein (CREB) activation and PSD95 messenger ribonucleic acid (mRNA) were observed. Our findings demonstrated that LCT could increase the PSD95 protein level via the ERα-dependent Akt pathway, and LCT might disrupt the up-regulation effect of E2 on PSD95 protein expression via this signaling pathway.