ABSTRACT
Recently, the robotic arm control system based on a brain-computer interface (BCI) has been employed to help the disabilities to improve their interaction abilities without body movement. However, it's the main challenge to implement the desired task by a robotic arm in a three-dimensional (3D) space because of the instability of electroencephalogram (EEG) signals and the interference by the spontaneous EEG activities. Moreover, the free motion control of a manipulator in 3D space is a complicated operation that requires more output commands and higher accuracy for brain activity recognition. Based on the above, a steady-state visual evoked potential (SSVEP)-based synchronous BCI system with six stimulus targets was designed to realize the motion control function of the seven degrees of freedom (7-DOF) robotic arm. Meanwhile, a novel template-based method, which builds the optimized common templates (OCTs) from various subjects and learns spatial filters from the common templates and the multichannel EEG signal, was applied to enhance the SSVEP recognition accuracy, called OCT-based canonical correlation analysis (OCT-CCA). The comparison results of offline experimental based on a public benchmark dataset indicated that the proposed OCT-CCA method achieved significant improvement of detection accuracy in contrast to CCA and individual template-based CCA (IT-CCA), especially using a short data length. In the end, online experiments with five healthy subjects were implemented for achieving the manipulator real-time control system. The results showed that all five subjects can accomplish the tasks of controlling the manipulator to reach the designated position in the 3D space independently.
ABSTRACT
In structure-based virtual screening, compound ranking through a consensus of scores from a variety of docking programs or scoring functions, rather than ranking by scores from a single program, provides better predictive performance and reduces target performance variability. Here we compare traditional consensus scoring methods with a novel, unsupervised gradient boosting approach. We also observed increased score variation among active ligands and developed a statistical mixture model consensus score based on combining score means and variances. To evaluate performance, we used the common performance metrics ROCAUC and EF1 on 21 benchmark targets from DUD-E. Traditional consensus methods, such as taking the mean of quantile normalized docking scores, outperformed individual docking methods and are more robust to target variation. The mixture model and gradient boosting provided further improvements over the traditional consensus methods. These methods are readily applicable to new targets in academic research and overcome the potentially poor performance of using a single docking method on a new target.
