Retrospective Study of the Epidemiology, Pathology, and Therapeutic Management in Patients With Mucinous Ovarian Tumors.

AIM: We sought to determine the epidemiology of mucinous ovarian tumors, the correlation between serum biomarkers and tumor status, and the outcomes of the management in different subtypes of mucinous ovarian tumors in a Chinese surgical cohort. METHODS: A total of 513 patients were enrolled from January 2009 to May 2017. The number of patients who had benign mucinous ovarian tumor, borderline mucinous ovarian tumor, or malignant mucinous ovarian tumor was pathologically quantified. All patients underwent surgery with or without postoperative adjuvant therapy. Prognosis was analyzed based on clinicopathological characteristics and the type of treatment received. Hyperthermic intraperitoneal chemotherapy efficacy and adverse effects in patients were also explored. RESULTS: In all, 383 (75%) patients were diagnosed as having benign mucinous ovarian tumor, 76 (14%) patients with borderline mucinous ovarian tumor, and 54 (5%) patients with malignant mucinous ovarian tumor. Levels of serum biomarkers increased as the tumors became more malignant. Patients with stage IA and IC (unilateral) malignant mucinous ovarian tumor who underwent fertility conserving surgery did not experience poorer prognoses when compared to those who received non-fertility conserving surgery. Hyperthermic intraperitoneal chemotherapy followed by chemotherapy significantly influenced survival rates in patients with a ruptured malignant mucinous ovarian tumor. CONCLUSIONS: Levels of serum tumor markers, carbohydrate antigen 125, carbohydrate antigen 199, carbohydrate antigen 242, and carcinoembryonic antigen may be useful in monitoring for malignant transformation. Fertility conserving surgery might be a preferable surgical procedure for patients with malignant mucinous ovarian tumor at early stage (IA and IC [unilateral]). Hyperthermic intraperitoneal chemotherapy appears to be a well-tolerated and promising postoperative adjuvant.

Chitosan-based zinc oxide nanoparticle for enhanced anticancer effect in cervical cancer: A physicochemical and biological perspective.

In this study, chitosan-assembled zinc oxide nanoparticle (CZNP) was successfully prepared for evaluated for its anticancer efficacy against cervical cancer cells. The CZNP particles were nanosized and spherical in shape. The zinc oxide nanoparticle (ZNP) and CZNP showed significant cytotoxicity in cervical cancer cells in a concentration-dependent manner. Results showed that the enhanced cytotoxicity was mainly attributed to the reactive oxygen species (ROS) generation in the cancer cells. The apoptosis assay further revealed that apoptosis was the main reason behind the cell killing effect of the zinc oxide nanoparticles. The apoptosis was further confirmed by the nuclear chromatin assay. Live dead assay showed increased red fluorescent cell for CZNP treated cancer cells. Overall, metal oxide present in nanoparticulate dimensions will be advantageous in imparting the cytotoxicity to cervical cancer cell.

miR-124 rs531564 polymorphism influences genetic susceptibility to cervical cancer.

Cervical cancer is the fourth most common cancer among women worldwide. It most frequently results from human papillomavirus (HPV) infection; however, recent evidence suggests that there may be underlying genetic factors, specifically in regions encoding microRNAs, dictating susceptibility to cervical cancer. This study investigated the relationship between the miR-124 rs531564 gene polymorphism and genetic susceptibility to cervical cancer in Chinese Han women. From January 2011 to July 2013, 158 Chinese Han cervical cancer patients and 260 healthy Chinese Han females were recruited to provide blood samples. The miR-124 rs531564 (C > G) polymorphism genotype was determined by polymerase chain reaction-based ligase detection reaction (PCR-LDR), and multivariate logistic regression analysis was used to deduce the relationship between the miR-124 rs531564 variant and cancer diagnosis. As expected, the incidence of HPV infection in cervical cancer patients was significantly higher than controls (P < 0.001). Logistic regression analysis showed that a CG genotype was associated with reduced risk of cervical cancer compared to the wildtype CC genotype (OR = 0.46, 95% CI: 0.19-0.92); the findings were similar when the variant genotypes were combined (CG + GG; OR = 0.42, 95% CI: 0.17-0.86). The G allele was associated with reduced risk of cervical cancer (OR = 0.45, 95% CI: 0.14-0.89) particularly among women over age 40 (OR = 0.31, 95% CI: 0.12-0.84), as well as reduced risk of HPV infection (OR = 0.59, 95% CI: 0.28-0.93). These results further support a role for genetic susceptibility in miR-124 rs531564 in determining the risk of cervical cancer in Chinese Han women.

Positive mood as a mediator of the relations among musical preference, postconsumption product evaluation, and consumer satisfaction.

This study of how positive mood mediates the influences of musical preference and postconsumption product evaluation on consumer satisfaction focuses specifically on a model in which positive mood fully mediates the influences. The proposed model is compared with two competing models, and a structural equation model is used to test and compare the three theory-driven models. This study sampled 247 students majoring in management at a single university. They had mean age of 23 yr. (SD=2.5). This study used questionnaires to measure subjects' evaluations of a cup of coffee, preference for the music broadcast in the coffee shop, positive mood, and satisfaction after they had the coffee. Analysis indicated that the proposed model outperformed the two competing models in describing the data using chi-square difference tests. Positive mood was identified as a full mediator of the relationship between musical preference and consumer satisfaction. Moreover, the results demonstrate for service managers the importance of creating positive consumer mood.