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1.
Chin J Integr Med ; 23(8): 617-624, 2017 Aug.
Article in English | MEDLINE | ID: mdl-25967608

ABSTRACT

OBJECTIVE: To elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury, and to detect the levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1), which is thought to play an important role in nerve regeneration. METHODS: Thirty-two adult male Sprague-Dawley rats were subjected to sciatic nerve crush injury and 16 rats (sham-operated group) went through a sham operation. Control group was given no treatment while tuina group received tuina therapy since day 7 post-surgery. Tuina treatment was performed once a day and lasted for 20 days. The sciatic functional index was examined every 5 days during the treatment session. The rats' gastrocnemius muscles were evaluated for changes in mass and immunohistochemistry techniques were performed to detect the levels of tPA and PAI-1. RESULTS: Tuina therapy improved the motor function of sciatic nerve injured rats (P<0.05), however, it did not increase muscle volume (P<0.05). Tuina downregulated the levels of tPA and PAI-1 (P<0.05). CONCLUSIONS: The present study implies that tuina treatment could accelerate rehabilitation of peripheral nerve injury.


Subject(s)
Down-Regulation , Medicine, Chinese Traditional , Sciatic Nerve/injuries , Sciatic Nerve/pathology , Tissue Plasminogen Activator/metabolism , Animals , Male , Muscles/pathology , Nerve Crush , Organ Size , Plasminogen Activator Inhibitor 1/metabolism , Rats, Sprague-Dawley
2.
Chin J Integr Med ; 23(12): 908-915, 2017 Dec.
Article in English | MEDLINE | ID: mdl-27145942

ABSTRACT

OBJECTIVE: To explore the protective effects of Tibetan medicine Zuo-Mu-A Decoction (, ZMAD) on the blood parameters and myocardium of high altitude polycythemia (HAPC) model rats. METHODS: Forty male Wistar rats were randomly divided into 4 groups by a random number table, including the normal, model, Rhodiola rosea L. (RRL) and ZMAD groups (10 in each group). Every group was raised in Lhasa to create a HAPC model except the normal group. After modeling, rats in the RRL and the ZMAD groups were administered intragastrically with RRL (20 mL/kg) and ZMAD (7.5 mL/kg) once a day for 2 months, respectively; for the normal and the model groups, 5 mL of distilled water was administered intragastrically instead of decoction. Then routine blood and hematologic rheology parameters were taken, levels of erythropoietin and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were tested, and ultrastructural change in the left ventricular myocardium was observed using transmission electron microscopy. RESULTS: Compared with the model group, ZMAD significantly reduced the red blood cell count, hemoglobin levels, whole blood viscosity at low/middle shear rates, plasma viscosity, erythrocyte electrophoretic time, erythropoietin and 8-OHdG levels, and also increased the erythrocyte deformation index (P<0.05). There was no difference in all results between the RRL and the ZMAD groups. The cardiac muscle fibers were well-protected, mitochondrial matrix swelled mildly and ultrastructure changes were less prominent in the ZMAD group compared with the model group. CONCLUSION: ZMAD has significant protective effects on the blood parameters against HAPC, and also has the beneficial effect in protecting against myocardial injury.


Subject(s)
Altitude Sickness/blood , Altitude Sickness/drug therapy , Medicine, Tibetan Traditional , Myocardium/pathology , Polycythemia/blood , Polycythemia/drug therapy , Protective Agents/therapeutic use , 8-Hydroxy-2'-Deoxyguanosine , Altitude Sickness/complications , Animals , Deoxyguanosine/analogs & derivatives , Deoxyguanosine/blood , Disease Models, Animal , Erythropoietin/blood , Myocardium/ultrastructure , Polycythemia/complications , Protective Agents/pharmacology , Rheology/drug effects
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