Ultrasound Monitoring of Simultaneous high-intensity focused ultrasound (HIFU) therapy using minimum-peak-sidelobe coded excitation.

Bipolar sequences can be readily transmitted by ultrasound (US) pulser hardware with the full driving voltage to boost the echo magnitude in B-mode monitoring of HIFU treatment. In this study, a novel single-transmit bipolar sequence with minimum-peak-sidelobe (MPS) level is developed not only to restore the image quality of US monitoring but also remove acoustic interference from simultaneous HIFU transmission. The proposed MPS code is designed with an equal number of positive and negative bits and the bit duration should be an integer multiple of the period of the HIFU waveform. In addition, different permutations of code sequence are searched in order to obtain the optimal encoding. The received imaging echo is firstly decoded by matched filtering to cancel HIFU interference and to enhance the echo magnitude of US monitoring. Then, Wiener filtering is applied as the second-stage pulse compression to improve the final image quality. Simulations and phantom experiments are performed to compare the single-transmit MPS decoding with conventional two-transmit methods such as pulse-inversion subtraction (PIS) and Golay decoding for their performance in simultaneous US monitoring of HIFU treatment. Results show that the MPS decoding effectively removes HIFU interference even in the presence of tissue motion. The image quality of PIS and Golay decoding, on the other hand, is compromised by the uncancelled HIFU components due to tissue motion. Simultaneous US monitoring of tissue ablation using the proposed MPS decoding has also demonstrated to be feasible in ex-vivo experiments. Compared to the notch filtering that also allows single-transmit HIFU elimination, the MPS decoding is preferrable because it does not suffer from the tradeoff between residual HIFU and speckle deterioration in US monitoring images.

Golay-Encoded Ultrasound Monitoring of Simultaneous High-Intensity Focused Ultrasound Treatment: A Phantom Study.

Ultrasound (US) imaging has high potential in monitoring high-intensity focused US (HIFU) treatment due to its superior temporal resolution. However, US monitoring is often hindered by strong HIFU interference, which overwhelms the echoes received by the imaging array. In this study, a method of Golay-encoded US monitoring is proposed to visualize the imaged object for simultaneous HIFU treatment. It effectively removes HIFU interference patterns in real-time B-mode imaging and improves the metrics of image quality, such as peak signal-to-noise ratio (PSNR), structural similarity (SSIM), and contrast ratio (CR). Compared to the pulse-inversion sequence, the N -bit Golay sequence can boost the echo magnitude of US monitoring by another N times and, thus, exhibits higher robustness. Simulations show that a sinusoidal HIFU waveform can be fully eliminated using Golay decoding when the bit duration of the N -bit Golay sequence ( N is the power of 4) coincides with either odd (Case I) or even (Case II) integer multiples of the HIFU quarter period. Experimental results also show that the Golay decoding with Case II can increase the PSNR of US monitoring images by more than 30 dB for both pulse- and continuous-wave HIFU transmissions. The SSIM index also effectively improves to about unity, indicating that the B-mode image with HIFU transmission is visually indistinguishable from that acquired without HIFU transmission. Though Case I is inferior to Case II in the elimination of even-order HIFU harmonic, they together enable a more flexible selection of imaging frequencies to meet the required image resolution and penetration for Golay-encoded US monitoring.