Association between life's essential 8 and frailty status among cancer survivors in the United States: a cross-sectional analysis.

BACKGROUND: Frailty not only affects disease survival but also impacts the long-term function and quality life of all adults diagnosed with and/or treated for cancer.The American Heart Association has introduced Life's Essential 8 (LE8) as a novel metric for assessing cardiovascular health. Currently, LE8's application in evaluating the frailty of cancer survivors remains unreported. This research seeks to explore the connection between LE8 scores and frailty levels in cancer survivors across the United States, thereby addressing a significant void in existing studies. METHODS: This study analyzed data from cancer survivors enrolled in the National Health and Nutrition Examination Surveys (NHANES) spanning the years 2005 to 2018, providing a comprehensive dataset. Multivariable logistic regression models were used to examine the linkage between LE8 rankings and frailty condition in cancer survivors. Furthermore, the study delved deeper into this correlation using restricted cubic spline (RCS) curves and subgroup analyses. RESULTS: In the fully adjusted model, an increased LE8 level was closely associated with a reduced odds ratio of frailty among cancer survivors, with an OR of 0.95 (95% CI: 0.94-0.96, p < 0.0001).This pattern persisted across different categorizations of LE8 into low, moderate, and high groups, demonstrating a consistent trend. The analysis revealed a non-linear relationship between LE8 scores and frailty status, further supporting a straightforward association (p-value for non-linearity = 0.0729). CONCLUSION: Studies have found that the higher the LE8 score, the less likely a cancer patient is to develop debilitating symptoms.This indicates that the LE8 scores may provide an opportunity for interventions aimed at improving the prognosis of cancer patients.

Tracing microplastics in rural drinking water in Chongqing, China: Their presence and pathways from source to tap.

Despite the significant attention given to microplastics in urban areas, our understanding of microplastics in rural drinking water systems is still limited. To address this knowledge gap, we investigated the presence and pathways of microplastics in rural drinking water system, including reservoir, water treatment plant (WTP), and tap water of end-users. The results showed that the treatment processes in the WTP, including coagulation-sedimentation, sand-granular active carbon filtration, and ultrafiltration, completely removed microplastics from the influent. However, the microplastic abundance increased during pipe transport from WTP to residents' homes, resulting in the presence of 1.4 particles/L of microplastics in tap water. This microplastic increase was also observed during the transportation from the reservoir to the WTP, suggesting that the plastic pipe network is a key source of microplastics in the drinking water system. The main types of polymers were PET, PP, and PE, and plastic breakdown, atmospheric deposition, and surface runoff were considered as their potential sources. Furthermore, this study estimated that rural residents could ingest up to 1034 microplastics annually by drinking 2 L of tap water every day. Overall, these findings provide essential data and preliminary insights into the fate of microplastics in rural drinking water systems.

Safe purification of rural drinking water by biological aerated filter coupled with ultrafiltration.

Water resources of many rural areas are usually lakes or reservoirs, which can be easily affected by run-off, non-point source pollution and are often of poorer quality compared with urban water sources. Drinking water supply in remote rural areas usually suffers from various challenges, such as the high cost of construction and maintenance of centralized drinking water treatment plants and pipe networks, due to the dispersed nature of villages, which are often located in varied and complex topographies. In this study, a combined process comprising biological aerated filter (BAF) combined with ultrafiltration was developed to treat polluted reservoir water. Organic matter indexes, turbidity, and chroma were used as indicators for the evaluation of the system performance. In a long-term experiment lasting 260 days, the combined process was tested under different values of critical operational parameters, including filler types and empty bed contact time (EBCT). Furthermore, the microbial communities in different BAF reactors were carefully evaluated at different times, finding that microorganisms with specific functions were enriched in the various BAF reactors. The combined process reached 85.5 % removal rate of DOC with an EBCT of 45 min and using granule active carbon (GAC) as filler. Most of the effluents of BAF reactors met the requirements for drinking water in China. The combined system showed practical potential for polluted water treatment in some rural areas.

Granular activated carbon (GAC) fixed bed adsorption combined with ultrafiltration for shale gas wastewater internal reuse.

Membrane processes are widely applied in shale gas flowback and produced water (SGFPW) reuse. However, particulate matters and organic matters aggravate membrane fouling, which is one of the major restrictions on SGFPW reuse. The present study proposed fixed bed adsorption using granular activated carbon (GAC) combined with ultrafiltration (UF) for the first time to investigate the treatment performance and membrane fouling mechanism. The adsorption of GAC for SGFPW was best described by the Temkin isotherm model and the pseudo-second-order kinetic model. GAC fixed bed pretreatment with different empty bed contact times (EBCT) (30, 60 and 90 min) showed the significant removal rate for dissolved organic carbon (DOC) and turbidity, which was 34.7%-42.4% and 98.1%-98.9%, respectively. According to characterization of UF membrane fouling layer, particulate matters and organic matters caused major part of membrane fouling. After being treated by GAC fixed bed, total fouling index (TFI) and hydraulic irreversible fouling index (HIFI) respectively decreased by more than 32.5% and 18.3% respectively, showing the mitigation effect of GAC fixed bed on membrane fouling. According to the XDLVO theory, GAC fixed bed also mitigated membrane fouling by reducing the hydrophobic interactions between the foulants and the UF membrane. The integrated GAC fixed bed-UF process produced high-quality effluents that met the water quality standards of SGFPW internal reuse, which was an effective technology of the SGFPW reuse.

Superwettable PVDF/PVDF-g-PEGMA Ultrafiltration Membranes.

Poly(vinylidene fluoride) (PVDF) is a common and inexpensive polymeric material used for membrane fabrication, but the inherent hydrophobicity of this polymer induces severe membranes fouling, which limits its applications and further developments. Herein, we prepared superwettable PVDF membranes by selecting suitable polymer concentration and blending with PVDF-graft-poly(ethylene glycol) methyl ether methacrylate (PVDF-g-PEGMA). This fascinating interfacial phenomenon causes the contact angle of water droplets to drop from the initial value of over 70° to virtually 0° in 0.5 s for the best fabricated membrane. The wetting properties of the membranes were studied by calculating the surface free energy by surface thermodynamic analysis, by evaluating the peak height ratio from Raman spectra, and other surface characterization methods. The superwettability phenomenon is the result of the synergetic effects of high surface free energy, the Wenzel model of wetting, and the crystalline phase of PVDF. Besides superwettability, the PVDF/PVDF-g-PEGMA membranes show great improvements in flux performance, sodium alginate (SA) rejection, and flux recovery upon fouling.

Improving the Performance of PVDF/PVDF-g-PEGMA Ultrafiltration Membranes by Partial Solvent Substitution with Green Solvent Dimethyl Sulfoxide during Fabrication.

Traditional organic solvents used in membrane manufacturing, such as dimethylformamide and tetrahydrofuran, are generally very hazardous and harmful to the environment and human health. Their total or partial substitution with green solvent dimethyl sulfoxide (DMSO) is proposed to fabricate membranes composed of poly(vinylidene fluoride) (PVDF) blended with PVDF-graft-poly(ethylene glycol) methyl ether methacrylate (PEGMA), with the purpose to accomplish a greener chemical process and enhance the membrane performance. Various organic solvent compositions were first investigated using the Hansen solubility theory, and the best mixture was thus applied experimentally. The membrane prepared by a ratio of N,N-dimethylacetamide/DMSO = 7:3 outperformed the membranes prepared by other solvent mixtures. This membrane showed high wetting behavior with the water contact angle declining from 71 to 7° in 18 s and a pure water flux reaching values larger than 700 L m-2 h-1 under 0.07 MPa applied hydraulic pressure. The membrane rejected sodium alginate at a rate of 87%, and nearly complete flux recovery was achieved following fouling and physical cleaning. The introduction of green chemistry concepts to PVDF/PVDF-g-PEGMA blended membranes is a step forward in the goal to increase the sustainability of membrane production.

Effect of volatile solvent and evaporation time on formation and performance of PVC/PVC-g-PEGMA blended membranes.

In order to further improve the performances of fabricated PVC/PVC-graft-poly(ethylene glycol) methyl ether methacrylate (PVC/PVC-g-PEGMA) blended membranes, we investigated the inner connections between affecting parameters during preparation and membrane performances. Two parameters including the composition of casting solutions and the solvent evaporation time were selected. In this study, PVC/PVC-g-PEGMA blended membranes were prepared by non-solvent induced phase separation (NIPS) using 1-methyl-2-pyrrolidinone (NMP) and tetrahydrofuran (THF) as mixing solvents. We found that (1) the membrane morphologies like surface pore size and porosity decreased as the ratio of THF to NMP increased, which resulted in the decrease in pure water flux and the increase of sodium alginate (SA) rejection ratio; (2) the presence of THF in the casting solution could significantly lower the membrane surface roughness compared to only using NMP as a solvent; (3) solvent evaporation for an appropriate time increased the hydrophilicity of the membrane. Among these findings, we achieved a membrane exhibiting the highest flux recovery ratio of 98.65 ± 0.85% with a mixing ratio of 1 : 9 (THF : NMP) at 60 s of evaporation time. High pollutant rejection and high flux recovery ratio were achieved. This study provides more insight into the PVC/PVC-g-PEGMA membrane and a more flexible approach to the application of PVC membranes.