1.
Org Lett
; 24(23): 4129-4134, 2022 Jun 17.
Article
in English
| MEDLINE
| ID: mdl-35652792
ABSTRACT
A palladium-catalyzed 1,4-carboamination of bromoarenes with diazo compounds and amines was developed. This reaction proceeds through a palladium-carbene that then generates a π-benzylpalladium intermediate, forming ipso C-C and para C-N bonds on bromoarenes in a regioselective manner. The successful application of this transformation to the rapid synthesis of an antitumor agent demonstrates its synthetic utility.