ABSTRACT
Background: Laryngeal cancer was one of the most common malignancies of the head in those years. It has become one of the most common causes of death due to its high recurrence rate and high metastasis rate. It was well known that platelets, especially activated platelets, promote the proliferation, division, and invasion of tumor cells. Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet aggregation function in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet aggregation function in laryngeal cancer. Materials and Methods: Between January 2015 and December 2016, we conducted a retrospective analysis of 203 patients who were diagnosed with laryngeal cancer consecutively. The patients were stratified by platelet aggregation function into two groups: low "adenosine diphosphate induced light transmittance aggregometry (ADP-induced LTA) ≤15.1" and high (ADP-induced LTA >15.1). Pathological tissues from different parts of the operation were collected and the pathologist determined the pathological type. We assessed the prognostic significance of platelet aggregation function using Kaplan-Meier curves and Cox regression. Results: The low cohort had a significantly higher lymphocyte count than the high cohort. Compared with the high cohort, the low cohort had significantly lower levels of platelet-to-lymphocyte ratio (PLR), ADP-induced LTA, and Interleukins (IL)-6. The ADP-induced LTA (hazard ratio, 1.212; P <0.001) was independently related with 5-year overall survival rate. Conclusion: Patients with ADP-induced LTA >15.1 experience poor outcomes. Platelet aggregation function, when elevated, could be a new prognostic indicator for laryngeal cancer.
ABSTRACT
The effects of one-step aging and double aging on the properties and microstructures of 7075 Al sheets were studied via mechanical property testing, scanning electron microscopy, and transmission electron microscopy. The results indicated that with continued one-step aging, the tensile and yield strengths of the Al sheets first increased rapidly with an increase in the treatment time to 8 h and then increased slightly with a further increase in the treatment time to 10 h. The tensile and yield strengths became constant after 16 h of treatment. The mechanical strength properties of the Al sheets peaked after 16 h of one-step aging. However, the double aging treatment provided better mechanical properties and working efficiency than the one-step aging treatment. The tensile strength and microhardness resulting from double aging were greater than those resulting from one-step aging by 5.87% and 8.71%, respectively. Herein, we quantified the contribution ofvarious strengthening mechanisms.
