ABSTRACT
Tobacco (Nicotiana tabacum Linn.) is a famous traditional herb used in folk medicine. The essential oils of tobacco have been demonstrated in modern studies to possess antioxidant, anti-inflammatory, and neuroprotective properties, while its anxiolytic effect has not been reported. The purpose of this study was to evaluate the anxiolytic effect of Yunnan tobacco essential oil (YTO) and Zimbabwe tobacco essential oil (ZTO) on mice. The constituents of YTO and ZTO were analyzed by GC/MS. The anxiolytic effect of YTO and ZTO (0.1%, 1%, and 10%, v/v) on male ICR mice was evaluated in the light-dark box test (LDB) and the elevated plus maze test (EPM) test via inhalation and transdermal administration. After the behavioral tests, salivary corticosterone levels in mice were measured. The behavioral analysis showed that the administration of both YTO and ZTO elevated the time that the mice spent in the light chamber in the LDB test compared to the untreated control. In the EPM test, YTO and ZTO increased the time spent in open arms and the number of entries into the open arms. In addition, both YTO and ZTO significantly decreased salivary corticosterone levels in mice (p ≤ 0.001). In summary, our results demonstrated that inhalation and transdermal administration of both YTO and ZTO showed anxiolytic effect on male ICR mice.
Subject(s)
Nicotiana/metabolism , Oils, Volatile/pharmacology , Plant Extracts/pharmacology , Animals , Anxiety/drug therapy , Behavior, Animal/drug effects , China , Female , Male , Mice , Mice, Inbred ICR , Motor Activity/drug effects , Oils, Volatile/administration & dosage , Plant Extracts/administration & dosageABSTRACT
Development of self-healing and photostimulated luminescent supramolecular polymeric materials is important for artificial soft materials. A supramolecular polymeric hydrogel is reported based on the host-guest recognition between a ß-cyclodextrin (ß-CD) host polymer (poly-ß-CD) and an α-bromonaphthalene (α-BrNp) polymer (poly-BrNp) without any additional gelator, which can self-heal within only about one minute under ambient atmosphere without any additive. This supramolecular polymer system can be excited to engender room-temperature phosphorescence (RTP) signals based on the fact that the inclusion of ß-CD macrocycle with α-BrNp moiety is able to induce RTP emission (CD-RTP). The RTP signal can be adjusted reversibly by competitive complexation of ß-CD with azobenzene moiety under specific irradiation by introducing another azobenzene guest polymer (poly-Azo).
Subject(s)
Fluorescence , Hydrogels/chemical synthesis , Polymers/chemical synthesis , Temperature , Hydrogels/chemistry , Macromolecular Substances/chemical synthesis , Macromolecular Substances/chemistry , Molecular Structure , Naphthalenes/chemistry , Photochemical Processes , Polymers/chemistry , beta-Cyclodextrins/chemistryABSTRACT
INHIBIT logic gates based on light-driven ß-cyclodextrin pseudo[1]rotaxane were conveniently fabricated in aqueous solution utilizing induced circular dichroism (ICD) and photocontrolled reversible room temperature phosphorescence (RTP) as output addresses respectively.
Subject(s)
Computers, Molecular , Light , Luminescence , Rotaxanes/chemistry , Temperature , beta-Cyclodextrins/chemistry , Circular Dichroism , Logic , Luminescent Measurements , Molecular StructureABSTRACT
A [Ru(bpy)(3)](2+) stopped "V" type guest molecule competitively prefers to thread into the cavity of cucurbit[7]uril to form a pseudo[2]rotaxane-like supramolecule because of the large binding constant between them rather than embedding into ß-cyclodextrin in a system containing these three components.
