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Organophotoelectrocatalytic C(sp2)-H alkylation of heteroarenes with unactivated C(sp3)-H compounds.
Chem Commun (Camb)
; 60(42): 5502-5505, 2024 May 21.
Article
in English
| MEDLINE
| ID: mdl-38699797
ABSTRACT
An organophotoelectrocatalytic method for the C(sp2)-H alkylation of heteroarenes with unactivated C(sp3)-H compounds through dehydrogenation cross-coupling has been developed. The C(sp2)-H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.