A Parametric Model for Characterizing Time-Variant Single Trials of Block-Design fNIRS Experiments.

Block-design is a popular experimental paradigm for functional near-infrared spectroscopy (fNIRS). Traditional block-design analysis techniques such as generalized linear modeling (GLM) and waveform averaging (WA) assume that the brain is a time-invariant system. This is a flawed assumption. In this paper, we propose a parametric Gaussian model to quantify the time-variant behavior found across consecutive trials of block-design fNIRS experiments. Using simulated data at different signal-to-noise ratios (SNRs), we demonstrate that our proposed technique is capable of characterizing Gaussian-like fNIRS signal features with ≥3dB SNR. When used to fit recorded data from an auditory block-design experiment, model parameter values quantitatively revealed statistically significant changes in fNIRS responses across trials, consistent with visual inspection of data from individual trials. Our results suggest that our model effectively captures trial-to-trial differences in response, which enables researchers to study time-variant brain responses using block-design fNIRS experiments.

The Use of Heart Rate Responses Extracted From Functional Near-Infrared Spectroscopy Data as a Measure of Speech Discrimination Ability in Sleeping Infants.

OBJECTIVES: Cardiac responses (e.g., heart rate changes) due to an autonomous response to sensory stimuli have been reported in several studies. This study investigated whether heart rate information extracted from functional near-infrared spectroscopy (fNIRS) data can be used to assess the discrimination of speech sounds in sleeping infants. This study also investigated the adaptation of the heart rate response over multiple, sequential stimulus presentations. DESIGN: fNIRS data were recorded from 23 infants with no known hearing loss, aged 2 to 10 months. Speech syllables were presented using a habituation/dishabituation test paradigm: the infant's heart rate response was first habituated by repeating blocks of one speech sound; then, the heart rate response was dishabituated with the contrasting (novel) speech sound. This stimulus presentation sequence was repeated for as long as the infants were asleep. RESULTS: The group-level average heart rate response to the novel stimulus was greater than that to the habituated first sound, indicating that sleeping infants were able to discriminate the speech sound contrast. A significant adaptation of the heart rate responses was seen over the session duration. CONCLUSION: The dishabituation response could be a valuable marker for speech discrimination, especially when used in conjunction with the fNIRS hemodynamic response.

Speech token detection and discrimination in individual infants using functional near-infrared spectroscopy.

Speech detection and discrimination ability are important measures of hearing ability that may inform crucial audiological intervention decisions for individuals with a hearing impairment. However, behavioral assessment of speech discrimination can be difficult and inaccurate in infants, prompting the need for an objective measure of speech detection and discrimination ability. In this study, the authors used functional near-infrared spectroscopy (fNIRS) as the objective measure. Twenty-three infants, 2 to 10 months of age participated, all of whom had passed newborn hearing screening or diagnostic audiology testing. They were presented with speech tokens at a comfortable listening level in a natural sleep state using a habituation/dishabituation paradigm. The authors hypothesized that fNIRS responses to speech token detection as well as speech token contrast discrimination could be measured in individual infants. The authors found significant fNIRS responses to speech detection in 87% of tested infants (false positive rate 0%), as well as to speech discrimination in 35% of tested infants (false positive rate 9%). The results show initial promise for the use of fNIRS as an objective clinical tool for measuring infant speech detection and discrimination ability; the authors highlight the further optimizations of test procedures and analysis techniques that would be required to improve accuracy and reliability to levels needed for clinical decision-making.

Maturation of the cortical auditory evoked potential in infants and young children.

The aim of this study was to evaluate the maturation of the cortical auditory evoked potential (CAEP) in humans. The participants in this experiment were 10 newborns (<7 days), 19 toddlers (13-41 months), 20 children (4-6 years) and 9 adults (18-45 years). CAEPs were obtained in response to low (400 Hz) and high (3000 Hz) tones and to the word token /baed/, all presented at 60 dB HL, at a rate of 0.22 Hz. Latency and amplitude measures were made for CAEP components P1, N1, P2 and N2 as a function of participant age, stimulus type and electrode montage. CAEP component latencies were relatively stable from birth to 6 years, but adults demonstrated significantly shorter latencies compared to infants and children. Components P1 and N2 decreased in amplitude, while components N1 and P2 increased in amplitude from birth to adulthood. Words evoked significantly larger CAEPs in newborns compared to responses evoked by tones, but in other age groups the effects of stimulus type on component amplitudes and latencies were less consistent. There was evidence of immature tonotopic organisation of the generators of N1 when responses from infants and young children were compared to those of adults. The scalp distribution of components N1 and P2 was clearly different in newborns and toddlers compared to children and adults. In the younger groups, both N1 and P2 were uniformly distributed across the scalp but in children and adults these components showed more focal distributions, with evidence of response laterality increasing with maturity. The results of the present study describe, for the first time, CAEPs recorded from multiple scalp electrodes, for tones and speech stimuli, in infants and children from birth to 6 years of age. Frequency-related differences in component amplitude were apparent at all ages reflecting development of tonotopic organisation of the CAEP neural generators.

Maturation of CAEP in infants and children: a review.

This paper reviews our current understanding of the development of the obligatory cortical auditory evoked potential (CAEP) components P1, N1, P2, and N2. Firstly, the adult CAEP is briefly reviewed with respect to its morphology, neural generators and stimulus-dependence. Secondly, age-related changes occurring from the newborn period through childhood and adolescence are reviewed. The focus is on the maturation of CAEP morphology, changes in the scalp topography of the various components, changes in their amplitude and latency and in their stimulus-dependence. This review identifies periods of development in which we have only limited understanding of cortical auditory processing, as revealed by evoked potentials.

Auditory evoked potentials from the cortex: audiology applications.

PURPOSE OF REVIEW: The audiological applications of cortical auditory evoked potentials are reviewed. Cortical auditory evoked potentials have some advantages compared with more commonly used techniques such as the auditory brainstem response, because they are more closely tied to perception and can be evoked by complex sounds such as speech. These response characteristics suggest that these potentials could be used clinically in the estimation of threshold and also to assess speech discrimination and perception. RECENT FINDINGS: Clinical uses of auditory evoked potentials include threshold estimation and their use as an electrophysiological index of auditory system development, auditory discrimination and speech perception, and the benefits from cochlear implantation, auditory training, or amplification. SUMMARY: Cortical auditory evoked potentials obtained in passively alert adults have a remarkably high correspondence with perceptual threshold. Acoustic features of complex sounds may be reflected in the waveform and latency of these potentials and so might be used to determine the integrity of neural encoding for such features and thus contribute to speech perception assessment. MMN and P3 have been used to discern discrimination abilities among groups of normal-hearing and hearing-impaired individuals; however, their sensitivity and specificity for testing an individual's abilities has not yet been established. Cortical auditory potentials are affected by listening experience and attention and so could be used to gauge the effects of aural habilitation. The presence of cortical potentials in children with auditory neuropathy appears to indicate residual hearing abilities. Parametric and developmental research is needed to further establish these applications in audiology.

Speech perception and cortical event related potentials in children with auditory neuropathy.

OBJECTIVES: 1) To investigate the unaided and aided speech perception abilities of children with auditory neuropathy (AN) and to compare their performance to children with sensorineural hearing loss. 2) To establish whether cortical event related potentials (ERPs) could be recorded in children with AN, and to determine the relationship between the presence of these responses and speech perception. DESIGN: Unaided and aided speech perception assessments (PBK words), and cortical-ERP testing was carried out in a group of 18 children with AN. Data also were obtained from a cohort of age and hearing level matched children with sensorineural hearing loss. RESULTS: The speech perception performance of the 15 children with AN able to complete a PBK-word assessment, fell into two distinct categories. The children either showed no open-set speech perception ability (7/15 cases), or performance levels similar to their sensorineural counterparts (8/15 cases). Approximately 50% of children with AN showed ERPs of normal latency, amplitude and morphology. In all cases, response presence (at normal latencies) was consistent with reasonable speech perception ability, and response absence was consistent with negligible speech perception. CONCLUSIONS: In approximately 50% of children with auditory neuropathy, the provision of amplification results in significant open-set speech perception improvements. The results confirm the previously published reports that speech perception ability cannot be reliably estimated from the behavioral audiogram in children with AN. Obligatory ERP test results may offer a means of predicting perceptual skills in newly diagnosed youngsters as the presence of ERPs (with age-appropriate latency and morphology) was correlated with significant open set speech perception abilities and amplification benefit. The absence of the ERP in contrast, indicated profound hearing disability evidenced by profound hearing loss and/or extremely poor speech perception.