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1.
Sci Rep ; 7(1): 11898, 2017 09 19.
Article in English | MEDLINE | ID: mdl-28928386

ABSTRACT

We design and fabricate elastically tunable monodisperse microcapsules using microfluidics and cross-linkable polydimethylsiloxane (PDMS). The overall stiffness of the microcapsules is governed by both the thickness and cross-link ratio of the polymer shell. Flowing suspensions of microcapsules through constricted spaces leads to transient blockage of fluid flow, thus altering the flow behavior. The ability to tune microcapsule mechanical properties enables the design of elastic microcapsules that can be tailored for desired flow behavior in a broad range of applications such as oil recovery, reactor feeding, red blood cell flow and chemical targeted delivery.

2.
West Indian Med J ; 50(1): 50-4, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11398289

ABSTRACT

The susceptibility of 39 toxin producing Clostridium difficile isolates from stools of hospitalized patients was determined, by disc diffusion, to six antibiotics. All but one isolate (toxin A negative) produced toxin A and toxin B. A wide variation in susceptibility to clindamycin, tetracycline and chloramphenicol was noted. Erythromycin and cotrimoxazole showed a clear-cut discrimination in resistance and susceptibility, while all isolates were sensitive to vancomycin. Erythromycin sensitive isolates demonstrated a significant association with diarrhoea (60.9%, 14/23, p < 0.001). These strains were predominantly found at the University Hospital of the West Indies (UHWI, 94.1%, 16/17). Strains resistant to erythromycin and clindamycin together were commonly found at the National Chest Hospital (NCH, 68.2%, 15/22). All erythromycin sensitive strains found at the NCH were from patients transferred to that hospital. These findings suggest that there is a common strain of C difficile (erythromycin resistant) at the NCH different from that found at the UHWI; the resistant pattern seen with isolates from the NCH was typical of toxigenic serogroup C strain and could be typed by the the disc diffusion method. Patients at the NCH who were colonized with either of the two strains of C difficile were likely to get diarrhoea, once there was suppression of the normal microflora by antibiotics and colonic overgrowth with C difficile.


Subject(s)
Anti-Bacterial Agents/pharmacology , Bacterial Proteins , Clostridioides difficile/drug effects , Diarrhea/etiology , Enterocolitis, Pseudomembranous/complications , Microbial Sensitivity Tests , Adolescent , Adult , Aged , Aged, 80 and over , Bacterial Toxins/biosynthesis , Clostridioides difficile/metabolism , Enterocolitis, Pseudomembranous/microbiology , Enterotoxins/biosynthesis , Female , Humans , Jamaica , Male , Middle Aged , Treatment Outcome
3.
West Indian med. j ; West Indian med. j;50(1): 50-54, Mar. 2001.
Article in English | LILACS | ID: lil-333413

ABSTRACT

The susceptibility of 39 toxin producing Clostridium difficile isolates from stools of hospitalized patients was determined, by disc diffusion, to six antibiotics. All but one isolate (toxin A negative) produced toxin A and toxin B. A wide variation in susceptibility to clindamycin, tetracycline and chloramphenicol was noted. Erythromycin and cotrimoxazole showed a clear-cut discrimination in resistance and susceptibility, while all isolates were sensitive to vancomycin. Erythromycin sensitive isolates demonstrated a significant association with diarrhoea (60.9, 14/23, p < 0.001). These strains were predominantly found at the University Hospital of the West Indies (UHWI, 94.1, 16/17). Strains resistant to erythromycin and clindamycin together were commonly found at the National Chest Hospital (NCH, 68.2, 15/22). All erythromycin sensitive strains found at the NCH were from patients transferred to that hospital. These findings suggest that there is a common strain of C difficile (erythromycin resistant) at the NCH different from that found at the UHWI; the resistant pattern seen with isolates from the NCH was typical of toxigenic serogroup C strain and could be typed by the the disc diffusion method. Patients at the NCH who were colonized with either of the two strains of C difficile were likely to get diarrhoea, once there was suppression of the normal microflora by antibiotics and colonic overgrowth with C difficile.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Enterocolitis, Pseudomembranous , Microbial Sensitivity Tests , Clostridioides difficile , Diarrhea , Anti-Bacterial Agents/pharmacology , Bacterial Toxins , Aged, 80 and over , Enterocolitis, Pseudomembranous , Clostridioides difficile , Treatment Outcome , Enterotoxins , Jamaica
4.
Acta pediátr. Méx ; 5(4): 160-3, 1984.
Article in Spanish | LILACS | ID: lil-24384

ABSTRACT

Se presenta un caso de leucemia granulocitica en un lactante. La rareza del problema en esta edad tiene interes para alertar al pediatra en esta patologia. Se hace una revision de la literatura en estos aspectos hematologicos


Subject(s)
Infant , Humans , Male , Leukemia, Myeloid
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