ABSTRACT
Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-ß (Aß) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral Aß inhibitors using supramolecular metal-organic cages.
Subject(s)
Amyloid beta-Peptides/antagonists & inhibitors , Macromolecular Substances/pharmacology , Metal-Organic Frameworks/pharmacology , Protein Aggregates/drug effects , Amyloid beta-Peptides/metabolism , Crystallography, X-Ray , Humans , Macromolecular Substances/chemistry , Metal-Organic Frameworks/chemistry , Models, Molecular , Molecular Conformation/drug effectsABSTRACT
A hexagonal porphyrin-based porous organic polymer, namely, CPF-1, was constructed by 3+2 ketoenamine condensation of the C2 -symmetric porphyrin diamine 5,15-bis(4-aminophenyl)-10,20-diphenylporphyrin and 1,3,5-triformylphloroglucinol. This material exhibits permanent porosity and excellent thermal and chemical stability. CPF-1 can be employed as a superior supporting substrate to immobilize Au nanoparticles (NPs) as a result of the strong interactions between Au NPs and the CPF support. An Au@CPF-1 hybrid was synthesized by an interfacial solution infiltration method with NaBH4 as reducing agent. Au NPs (5â nm) grew on CPF-1 and were distributed without aggregation. Moreover, Au@CPF-1 exhibits superior catalytic activity compared to many other reported Au-based catalysts for the reduction of 4-nitrophenol in the presence of NaBH4 . In addition, Au@CPF-1 has excellent stability and recyclability, and it can be reused for three successive reaction cycles without loss of activity. The dense distribution of phenyl rings on the channel walls of the CPF support can reasonably be regarded as the active sites that adsorb the 4-nitrophenol molecule through hydrogen-bonding and C-Hâ â â π interactions, as was confirmed by the X-ray structure of model compound DAPP-Benz.
ABSTRACT
Four pairs of enantiomers of water-stable tetrahedral metal-organic cages [Ni4L6](8+) were facilely synthesized. They efficiently stabilized antiparallel G-quadruplex DNA with moderate enantioselectivity, and displayed promising cytotoxicity against the human cancer cell lines HCT116, HepG2 and MCF-7. These results provide a new insight into the rational design of chiral G-quadruplex-based anticancer agents.
Subject(s)
Antineoplastic Agents/pharmacology , Coordination Complexes/pharmacology , DNA, Neoplasm/drug effects , G-Quadruplexes/drug effects , Antineoplastic Agents/chemistry , Cell Proliferation/drug effects , Coordination Complexes/chemistry , Crystallography, X-Ray , Dose-Response Relationship, Drug , Drug Screening Assays, Antitumor , HCT116 Cells , Hep G2 Cells , Humans , Ligands , MCF-7 Cells , Models, Molecular , Molecular Structure , Stereoisomerism , Structure-Activity RelationshipABSTRACT
The first SCO@SCO core-shell nanomaterials have been synthesized by the step-by-step microemulsion method. The observed gyroscopic core-shell nanocomposites exhibit three-step spin crossover behaviour with thermal hysteresis at around room temperature. This offers an efficient and novel strategy for the development of multistable SCO materials.
