1.
Signal Transduct Target Ther
; 7(1): 393, 2022 12 08.
Article
in English
| MEDLINE
| ID: mdl-36481755
Subject(s)
Neoplasms , Humans , Neoplasms/drug therapy , Neoplasms/genetics , Ubiquitin Thiolesterase/genetics
2.
Org Biomol Chem
; 17(33): 7651-7654, 2019 09 07.
Article
in English
| MEDLINE
| ID: mdl-31353383
ABSTRACT
An iridium-catalyzed diastereoselective amination of alcohols with chiral tert-butanesulfinamide was developed under basic conditions, affording the optically active secondary sulfinamides in high yields and diastereoselectivities. The removal of the sulfinyl group from sulfonamides allowed a facile access to a wide range of α-chiral primary amines. This synthetic strategy was further applied in the synthesis of the marketed pharmaceuticals (S)-rivastigmine and NPS R-568.