Decreased Hemodynamic Responses in Left Parietal Lobule and Left Inferior Parietal Lobule in Older Adults with Mild Cognitive Impairment: A Near-Infrared Spectroscopy Study.

BACKGROUND: The brain activation patterns of mild cognitive impairment (MCI) are still unclear and they involve multiple brain regions. Most previous studies have focused on abnormal activation in the frontal and temporal lobes, with few investigating the entire brain. OBJECTIVE: To identify and compare the changes in cerebral hemodynamics and abnormal activation patterns in the entire brain of MCI patients and healthy older adults. METHODS: Patients with MCI (n = 22) and healthy controls (HC, n = 34) matched by age, education levels, sex, and mental state were enrolled. They performed the same letter and category verbal fluency test (VFT) tasks while their behavioral performance and global cerebral hemodynamics were analyzed. RESULTS: The performance during the category VFT task was significantly better than that during the letter VFT task across all participants (HC: correct: p < 0.001; intrusions: p < 0.001; MCI: correct: p < 0.001; intrusions: p < 0.001). The number of correct words during the letter and category VFT tasks was significantly higher in the HC group than in the MCI group (p < 0.001). The deoxygenated-hemoglobin (HbR) concentrations in the left parietal lobule (p = 0.022) and left inferior parietal lobule (p = 0.034) were significantly different during the category VFT task. CONCLUSION: The differences between HC and MCI groups were greater in the category task. The HbR concentration was more sensitive for the category VFT task and concentration changes in the left parietal lobule and left inferior parietal lobule may be useful for clinical screening and application; thus, they deserve more attention.

Motion artifact correction for resting-state neonatal functional near-infrared spectroscopy through adaptive estimation of physiological oscillation denoising.

Significance: Functional near-infrared spectroscopy (fNIRS) for resting-state neonatal brain function evaluation provides assistance for pediatricians in diagnosis and monitoring treatment outcomes. Artifact contamination is an important challenge in the application of fNIRS in the neonatal population. Aim: Our study aims to develop a correction algorithm that can effectively remove different types of artifacts from neonatal data. Approach: In the study, we estimate the recognition threshold based on the amplitude characteristics of the signal and artifacts. After artifact recognition, Spline and Gaussian replacements are used separately to correct the artifacts. Various correction method recovery effects on simulated artifact and actual neonatal data are compared using the Pearson correlation ( R ) and root mean square error (RMSE). Simulated data connectivity recovery is used to compare various method performances. Results: The neonatal resting-state data corrected by our method showed better agreement with results by visual recognition and correction, and significant improvements ( R = 0.732 ± 0.155 , RMSE = 0.536 ± 0.339 ; paired t -test, ** p < 0.01 ). Moreover, the method showed a higher degree of recovery of connectivity in simulated data. Conclusions: The proposed algorithm corrects artifacts such as baseline shifts, spikes, and serial disturbances in neonatal fNIRS data quickly and more effectively. It can be used for preprocessing in clinical applications of neonatal fNIRS brain function detection.

Implementation of digital optical phase conjugation with embedded calibration and phase rectification.

Focused and controllable optical delivery beyond the optical diffusion limit in biological tissue has been desired for long yet considered challenging. Digital optical phase conjugation (DOPC) has been proven promising to tackle this challenge. Its broad applications, however, have been hindered by the system's complexity and rigorous requirements, such as the optical beam quality, the pixel match between the wavefront sensor and wavefront modulator, as well as the flatness of the modulator's active region. In this paper, we present a plain yet reliable DOPC setup with an embedded four-phase, non-iterative approach that can rapidly compensate for the wavefront modulator's surface curvature, together with a non-phase-shifting in-line holography method for optical phase conjugation in the absence of an electro-optic modulator (EOM). In experiment, with the proposed setup the peak-to-background ratio (PBR) of optical focusing through a standard ground glass in experiment can be improved from 460 up to 23,000, while the full width at half maximum (FWHM) of the focal spot can be reduced from 50 down to 10 µm. The focusing efficiency, as measured by the value of PBR, reaches nearly 56.5% of the theoretical value. Such a plain yet efficient implementation, if further engineered, may potentially boost DOPC suitable for broader applications.

Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media.

Manipulating and focusing light deep inside biological tissue and tissue-like complex media has been desired for long yet considered challenging. One feasible strategy is through optical wavefront engineering, where the optical scattering-induced phase distortions are time reversed or pre-compensated so that photons travel along different optical paths interfere constructively at the targeted position within a scattering medium. To define the targeted position, an internal guidestar is needed to guide or provide a feedback for wavefront engineering. It could be injected or embedded probes such as fluorescence or nonlinear microspheres, ultrasonic modulation, as well as absorption perturbation. Here we propose to use a magnetically controlled optical absorbing microsphere as the internal guidestar. Using a digital optical phase conjugation system, we obtained sharp optical focusing within scattering media through time-reversing the scattered light perturbed by the magnetic microsphere. Since the object is magnetically controlled, dynamic optical focusing is allowed with a relatively large field-of-view by scanning the magnetic field externally. Moreover, the magnetic microsphere can be packaged with an organic membrane, using biological or chemical means to serve as a carrier. Therefore, the technique may find particular applications for enhanced targeted drug delivery, and imaging and photoablation of angiogenic vessels in tumours.