ABSTRACT
OBJECTIVE@#To explore the relationship between the sequence variation of the promoter region (-1543 approximately -1160) of STK11 gene and the risk of developing Peutz-Jeghers syndrome (PJS).@*METHODS@#The sequences of the promoter region of 14 PJS patients (7 patients are inherited and the other 7 patients are sporadic) and 42 normal individuals were PCR amplified and then sequenced.@*RESULTS@#A new single nucleotide polymorphism (SNP) G/T (-1275) in STK11 promoter region was identified. The frequency of genotype GG, GT, and TT was 53.3%, 26.7%, and 20%, respectively among PJS patients and 33.3%, 64.3%, and 2.4%, respectively among the normal individuals. The frequency of genotype GG and TT among patients was significantly higher than that among the normal individuals, and the frequency of genotype GT among patients was significantly lower than that among the normal individuals (chi(2)=8.521, P<0.05).@*CONCLUSION@#G/T(-1275) in STK11 promoter region is a new SNP. The genotype of this new SNP may relate to the risk of developing Peutz-Jeghers syndrome (PJS) deserve further research.
Subject(s)
Humans , Base Sequence , Gene Frequency , Genotype , Molecular Sequence Data , Peutz-Jeghers Syndrome , Genetics , Polymorphism, Genetic , Promoter Regions, Genetic , Genetics , Protein Serine-Threonine Kinases , GeneticsABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Simotang oral liquid and glycerin enema on the patients' bowel sound (BS) restoration and anal exhaust after abdominal gynecological operation.</p><p><b>METHOD</b>Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed.</p><p><b>RESULTS</b>Compared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance (P < 0.05); but the difference between the two treated groups was insignificant (P > 0.05).</p><p><b>CONCLUSION</b>Simotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.</p>
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Middle Aged , Pregnancy , Abdomen , Administration, Oral , Constipation , Drug Therapy , Drugs, Chinese Herbal , Enema , Gastrointestinal Motility , Glycerol , Myoma , General Surgery , Postoperative Complications , Drug Therapy , Pregnancy, Ectopic , General Surgery , Uterine Neoplasms , General SurgeryABSTRACT
Based on their multiple years of personal experiences in hospital administration,authors of this article point out that medical service,humanistic service,and emotional service should be the core aspects in the current hospital competition.Medical professionalism embodied in the three levels of consciousness,behaviors,and regulations should be the main subject in the research on the role of medical ethics in hospital administration and medical treatment behaviors.It is an urgent ethical requirement and the chief task for hospital administrators to achieve humanistic medical service through humanistic administration of hospitals.
