GIS-based risk assessment of flood disaster in the Lijiang River Basin.

This study is designed to provide a scientific reference for the establishment of rainstorm and flood disaster prevention system in Guilin region and improve the risk assessment of rainstorm and flood disasters. To realize the goal, a flood risk evaluation model is established by weight analysis methods including the entropy weight method and the analytic hierarchy process from 3 aspects, i.e., risk of disaster causing factors, sensitivity of disaster-pregnant environment and vulnerability of disaster bearing body. For the model, the daily precipitation 1980-2020 of 6 representative national meteorological stations in the Lijiang River Basin was used as reference data of disaster causing factors; six indicators, i.e., NDVI, river network density, geological hazard, slope, slope aspect and terrain undulation were selected as the sensitivity of disaster-pregnant environment; NPP, potential of farmland production, and population density were taken as the criteria for determining the vulnerability of disaster bearing capacity. Meanwhile, ArcGIS was used for analysis and calculation to complete the risk assessment of flood disaster in Lijiang River Basin, Guangxi. The results indicate that: (1) the hazard level of flood disaster causing factors in Lijiang River Basin shows a decreasing distribution pattern from north to south, and high-risk areas cover 3108.47 km2, accounting for 21.29%; (2) the stability grade of disaster-pregnant environment shows a decreasing trend from the surrounding mountains to the plains, and the low-stability and lower-stability areas are mostly found in the low-lying areas around Lijiang River, with an area of 4218.63 km2, accounting for 28.69%; (3) the vulnerability of the disaster bearing body is generally at a low level, and the areas with high level cover 246.96 km2, accounting for only 1.69%; (4) under the combined effect of the above factors, the northern part of Guilin City in the Lijiang River Basin has a high risk of flood disaster.

Hyperuricemia is an independent risk factor for renal pathological damage and poor prognosis in lupus nephritis patients / 中南大学学报(医学版)

To explore the correlation between hyperuricemia and renal damage in patients with lupus nephritis (LN).
 Methods: The data for clinical features, laboratory and renal pathological examination were collected from 177 renal biopsy-proven LN patients with or without hyperuricemia and were retrospectively analyzed to determine the correlation between serum uric acid and renal damage.
 Results: LN patients with hyperuricemia group had higher rate of hypertension and higher level of blood urea nitrogen and serum creatinine while lower estimated glomerular filtration rate (eGFR) and lower positive rate of anti-U1RNP antibody (P<0.05). In the LN patients with hyperuricemia group, renal pathological scores, including acitive index, chronic index and tubulointerstitial lesions, were higher than those in the LN patients without hyperuricemia group (P<0.05). The level of serum uric acid was positively correlated with serum creatinine, renal pathological classification and renal pathological scores while negatively correlated with eGFR (P<0.05).
 Conclusion: LN patients with hyperuricemia are associated with more serious renal damage. Hyperuricemia is an important predictor for poor prognosis in patients with LN.

Cardioprotection of Shenfu preparata on cardiac myocytes through cytochrome P450 2J3 / 中西医结合学报

To evaluate whether Shenfu injection (SFI) protects against cardiac myocyte injury induced by Fupian injection (FPI) in vitro.

Association between elevated visfatin and carotid atherosclerosis in patients with chronic kidney disease / 中南大学学报(医学版)

OBJECTIVE@#To determine the levels of visfatin in patients with chronic kidney disease (CKD) and to explore the relationship between visfatin levels and caroid atherosclerosis in CKD patients.@*METHODS@#A total of 180 CKD patients (102 non-dialyzed patients and 78 dialysis patients) and 42 healthy subjects enrolled in this study. The serum levels of visfatin, IL-6, and high sensitive C-reactive protein (hsCRP) were measured by ELISA. Common carotid arteries intima-media thickness (CCA-IMT), cross-sectional calculated intima-media thickness (c IMT) area and atherosclerotic plaque were detected by non-invasive high-resolution B-mode ultrasonography.@*RESULTS@#The serum levels of visfatin, IL-6 and hsCRP were significantly increased in CKD patients compared with age matched healthy subjects (P<0.01). The serum levels of visfatin, IL-6 and hsCRP in the dialyzed patients were significantly higher than those in non-dialyzed patients (P<0.05). Visfatin levels increased with the progression of renal dysfunction and inversely related to creatinine clearance (Ccr) in non-dialyzed patients (r=-0.415, P<0.05). Patients with carotid artery plaques showed significantly higher levels of visfatin[(34.22±7.96) ng/mL)] compared with those without plaques [(28.24±6.18) ng/mL, P<0.05]. The serum levels of visfatin were closely correlated with IL-6 (r=0.548, P<0.001), hsCRP (r=0.430, P<0.001), CCA-IMT (r=0.462, P<0.05), and c IMT area (r=0.411, P<0.05). After adjusting for GFR, age, gender, and other risk factors associated with atherosclerosis, multiple stepwise regression analysis showed that serum visfatin is a independent risk factor for CCA-IMT (β=0.433, P<0.01) and c IMT area (β=0.412, P<0.01).@*CONCLUSION@#The serum level of visfatin increase with the progression of CKD and should be considered to be a new risk factor for atherosclerosis in CKD.