ABSTRACT
The ubiquitously expressed multifunctional protein, CUEDC2 (CUE domain-containing 2), is involved in many physiological and pathological processes, including the cell cycle regulation and inflammation. Although it is known that CUEDC2 is expressed disparately in breast cancer, ovarian carcinoma, hepatocellular carcinoma, cholangiocarcinoma, glioma, lung adenocarcinoma, colon cancers, and is involved in the Warburg's effect, its role in oncogenesis remains to be further explored. In this review, we examine the expression of CUEDC2 in various tumors, and discuss several fundamental signaling pathways that are impacted by CUEDC2.
Subject(s)
Carcinogenesis/metabolism , Carrier Proteins/metabolism , Membrane Proteins/metabolism , Adaptor Proteins, Signal Transducing , Adenocarcinoma/metabolism , Animals , Brain Neoplasms/metabolism , Breast Neoplasms/metabolism , Carcinoma, Hepatocellular/metabolism , Cell Cycle , Cholangiocarcinoma/metabolism , Female , Gene Expression Profiling , Gene Expression Regulation, Neoplastic , Glioma/metabolism , Humans , Inflammation , Liver Neoplasms/metabolism , Lung Neoplasms/metabolism , Macrophages/pathology , Male , Mice , Mitosis , NF-kappa B/metabolism , Ovarian Neoplasms/metabolismABSTRACT
Freeze-thaw erosion, one of the main types of soil erosion, is widely distributed in China. The distribution and harm of the combined erosion of freeze-thaw and other forces were greater than freeze-thaw erosion. We reviewed related research progress of the effects of freeze-thaw on soil phy-sical and chemical properties, wind erosion, and water erosion, based on literatures from China and abroad. Under the condition of freeze-thaw, soil water was transported and soil structure was dama-ged. Soil porosity, bulk density, shear strength, aggregate stability and organic matter were all changed. The change tendency and amplitude were related to soil texture and the degree of freeze-thaw. The occurrence and process of soil wind erosion and water erosion were influenced by the condition of freeze-thaw. Soil erodibility and erosion intensity increased as a result of the changes of soil physical and chemical properties. At present, the research on freeze-thaw mainly based on indoor simulation, which was quite different from the actual freeze-thaw process in the field. The conclusions obtained were not unified or even contrary due to different test conditions. Therefore, through combining indoor simulation and field survey, to strengthen the research of soil erosion mechanism of freeze-thaw conditions was the focus of the future research, which was of great significance for forecasting and preventing of soil erosion in the periods of thawing and the regions of seasonal freeze-thaw.
Subject(s)
Environmental Monitoring , Geological Phenomena , Soil/chemistry , Wind , China , Freezing , WaterABSTRACT
BACKGROUND/AIMS: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. METHODS: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data. RESULTS: There were 66 patients diagnosed with small intestine angiosarcoma. The onset age ranged from 24-92 years old. There were 24 patients diagnosed before the year 2000, and 42 patients were diagnosed after 2000. The data indicated that 49 cases were diagnosed as primary disease, and the remaining 15 cases were secondary disease. The main clinical symptoms were nonspecific and included gastrointestinal (GI) bleeding and abdominal pain. Additionally, we found multi-center foci were one of the characteristics of this disease. Radiation-induced small intestine angiosarcoma (RSIA) is a special type of disease with a similar prognosis. This type was more frequent in females and decreased after the year 2000. We also found that GI bleeding was less common in RSIA cases. The log-rank test results revealed that old-age, poor differentiation, and GI bleeding were associated with worse prognosis. Surgical treatment showed a trend toward a prolonged survival time. However, the result was not statistically significant. Our results show treatment with adjuvant therapy improved prognosis. The multivariate Cox analysis demonstrated adjuvant therapy was an independent indicator of a favorable outcome in small intestine angiosarcoma patients. CONCLUSION: Pay attention to the unexplained gastrointestinal bleeding could lead to a faster diagnosis and control of small intestine angiosarcoma. Furthermore, treatments including adjuvant therapy can effectively improve the prognosis.
Subject(s)
Hemangiosarcoma/diagnosis , Intestinal Neoplasms/diagnosis , Adult , Aged , Aged, 80 and over , Chemotherapy, Adjuvant , Databases, Factual , Female , Gastrointestinal Hemorrhage , Hemangiosarcoma/mortality , Hemangiosarcoma/therapy , Humans , Intestinal Neoplasms/mortality , Intestinal Neoplasms/therapy , Kaplan-Meier Estimate , Male , Middle Aged , Prognosis , Proportional Hazards Models , Retrospective Studies , Sex Factors , Young AdultABSTRACT
<p><b>OBJECTIVE</b>To study the incidence of injuries among residents living in the countryside of Huanghe delta area.</p><p><b>METHODS</b>A household questionnaire survey was conducted to 15 276 residents in 20 villages of Dongying municipality of Shandong province with a stratified-cluster sampling on their injuries from March 1, 2002 to February 28, 2003. Data were analyzed with Excel 2000 and SPSS 11.0 software.</p><p><b>RESULTS</b>The crude incidence of injuries was 5.90% in total, and the standardized incidence was 5.93%. It was higher in men (7.79%) than in women (4.03%). There were 19 deaths with 20 cripples. The standardized death rate was 122.56 per 100 000 with leading causes of injuries was blunt or by sharp articles (24.61%), traffic accident (24.17%), falls (22.62%) and animal bites (13.08%). Peak incidence of age group was high in 25 - 54 age group and 0 - 4 age group (> 6.0%). 267 cases (29.60%) inpatients had had about 15.89 days hospitalization for each case. Rest of each case with injury had 19.20 days of rest. Direct economic loss for treatment would cost 904.85 RMB Yuan and 10.15 days with care takers and 221.88 RMB for other cost. The potential years of life lost was 24 years, the working years of life lost was 19.6 year, the valued years of life lost was 8.7 year, and the standardized period expected years of life lost was 31.73 year.</p><p><b>CONCLUSION</b>Injury was common and frequently occurred among residents in the countryside of rural Huanghe delta areas, that seriously endangered the health care systems and burden on families.</p>
