ABSTRACT
CYP 2C8, which carries out the oxidative metabolism of at least 5% of clinical drugs, has attracted increasing attention in recent years. New drugs (substances), inducers and inhibitors of CYP 2C8 have been developed and the drug metabolism has been investigated to understand the clinical role of CYP2C8. The cases of CYP2C8 genetic polymorphisms linked to diseases have increased and have been investigated. Herein, important progress in these areas has been reviewed with an emphasis on drug metabolism. Polymorphisms, diseases related to CYP2C8, some important drugs (substances) and inhibitors are reviewed and discussed.
Subject(s)
Aryl Hydrocarbon Hydroxylases/metabolism , Pharmaceutical Preparations/metabolism , Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors , Aryl Hydrocarbon Hydroxylases/chemistry , Cytochrome P-450 CYP2C8 , Humans , Models, Molecular , Pharmaceutical Preparations/chemistryABSTRACT
Objective To investigate the preventive effect of fine management of hospital infection quality of obstetric rooming-in,in order to reduce the incidence of hospital infection.Methods Fine management run through each link of the hospital infection control from 2010,including a sound management system,strict implementation of the regulations for the operation and management of hand hygiene system,improvement of the building layout and work flow,strengthening the company staff and the ward environment management and monitoring,and make the management of hospital infection more standard.Results The obstetric rooming-in nosocomial infection rate decreased from 3.90％ in 2010 to 0.78％ in 2012.Fine management significantly reduced the incidence of nosocomial infection in our hospital.Conclusions The implementation of fine management in obstetric rooming-in is conducive to the effective control of nosocomial infection and promotion of maternal and child safety.
