1.
Mar Drugs
; 16(11)2018 Oct 23.
Article
in English
| MEDLINE
| ID: mdl-30360574
ABSTRACT
Five new acylated aminooligosaccharides (1â»5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.
Subject(s)
Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/pharmacology , Oligosaccharides/chemistry , Oligosaccharides/pharmacology , Pancreatic alpha-Amylases/antagonists & inhibitors , Streptomyces/chemistry , Animals , Carbohydrate Sequence , Cell Proliferation/drug effects , Glycoside Hydrolase Inhibitors/isolation & purification , Oligosaccharides/isolation & purification , Swine
2.
Mol Plant
; 11(10): 1308-1311, 2018 10 08.
Article
in English
| MEDLINE
| ID: mdl-29885474