ABSTRACT
BACKGROUND: Whether hyperbaric oxygen therapy (HBOT) can cause paradoxical herniation is still unclear. CASE SUMMARY: A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after surgery. HBOT was administered 22 d after surgery due to speech impairment. Paradoxical herniation appeared on the second day after treatment, and the patient's condition worsened after receiving mannitol treatment at the rehabilitation hospital. After timely skull repair, the paradoxical herniation was resolved, and the patient regained consciousness and had a good recovery as observed at the follow-up visit. CONCLUSION: Paradoxical herniation is rare and may be caused by HBOT. However, the underlying mechanism is unknown, and the understanding of this phenomenon is insufficient. The use of mannitol may worsen this condition. Timely skull repair can treat paradoxical herniation and prevent serious complications.
ABSTRACT
Human C-reactive protein (CRP) is an acute phase protein which arises rapidly and tremendously in serum when the subject is exposed to infection and tissue injury. CRP can effectively opsonize by both activating the complement classical pathway and potentiating the phagocytosis of phagocytes, thus clearing the invading pathogens and tissue cells undergoing injury, necrosis and apoptosis and performing an important protective role in the innate immune system. It has been over 70 years since CRP was first discovered. Traditional wisdom holds that CRP is a non-specific marker of inflammation. However, accumulating evidence during the last decade has elucidated that CRP, plays a direct role in the inflammation and cardiovascular disease such as atherosclerosis and can be recognized as the most powerful risk factor and predicator of cardiovascular disease, hence at present receiving attention worldwidely.
