Efficacy and Safety of Traditional Chinese Medicines as a Complementary Therapy Combined With Chemotherapy in the Treatment of Gastric Cancer: An Overview of Systematic Reviews and Meta-Analyses.

BACKGROUND: In China, traditional Chinese medicines (TCMs), as a complementary therapy combined with chemotherapy, is widely used in the treatment of gastric cancer (GC). In order to systematically evaluate and synthesize existing evidence to provide a scientific basis for the efficacy and safety of this complementary therapy, we present an overview of systematic reviews (SRs) and meta-analyses (MAs) on the topic of TCMs as a complementary therapy in combination with chemotherapy for the treatment of GC. METHODS: SRs/MAs on TCMs combined with chemotherapy for GC were comprehensively searched in 8 databases. Methodological quality, risk of bias, reporting quality, and quality of evidence were assessed using the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2), the Risk of Bias in Systematic (ROBIS) scale, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020), as well as the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. RESULTS: Thirteen published SRs/MAs were included in our study. In terms of methodology, all SRs/MAs were considered to be of very low quality. Only 3 SRs/MAs has been assessed as low risk of bias. None of the SRs/MAs has been fully reported on the checklist. A total of 97 outcome indicators extracted from the included SRs/MAs were evaluated, and only 1 item was assessed as high quality. CONCLUSIONS: TCMs may be an effective and safe complementary therapy in combination with chemotherapy for the treatment of GC. However, this conclusion must be treated with caution as the quality of the evidence provided by SRs/MAs is generally low.

Sprayable alginate hydrogel dressings with oxygen production and exosome loading for the treatment of diabetic wounds.

Chronic wound unhealing is a common complication in diabetic patients, which is mainly caused by tissue hypoxia, slow vascular recovery, and a long period of inflammation. Here we present a sprayable alginate hydrogel (SA) dressing consisting of oxygen-productive (CP) microspheres and exosomes (EXO) to promote local oxygen generation, accelerate macrophage towards M2 polarization, and improve cell proliferation in diabetic wounds. Results show that the release of oxygen continues for up to 7 days, reducing the expression of hypoxic factors in fibroblasts. In vivo, the diabetic wounds experiment showed that the CP/EXO/SA dressing apparently accelerated full-thickness wound healing characteristics such as the promotion of wound healing efficiency, rapid re-epithelization, favorable collagen deposition, abundant angiogenesis at the wound beds, and shortened inflammation period. EXO synergistic oxygen (CP/EXO/SA) dressing suggests a promising treatment measure for diabetic wounds.

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines.

The SARS-CoV-2 variants B.1.617.1 (Kappa) contain multiple mutations in the spike protein. However, the effect of B.1.617.1 lineage-related mutants on viral infectivity and inactivated-virus vaccine efficacy remains to be defined. We therefore constructed 12 B.1.617.1-related pseudoviruses and systematically studied the effects of mutations on virus infectivity and neutralization resistance to convalescent and inactivated virus vaccine sera. Our results show that the B.1.617.1 variant exhibited both higher infectivity and neutralization resistance in sera at 1 or 3 months after vaccination of 28 individuals and at 14 and 200 days after discharge of 15 convalescents. Notably, 89% of vaccines and 100% of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against one single mutation: E484Q. Besides, we found a significant decrease in neutralizing activity in convalescent patients and BBIBP-CorV vaccines for B.1.1.529. These findings demonstrate that inactivated-virus vaccination or convalescent sera showed reduced, but still significant, neutralization against the B.1.617.1 variant.

Robust Tightly-Coupled Visual-Inertial Odometry with Pre-built Maps in High Latency Situations.

In this paper, we present a novel monocular visual-inertial odometry system with pre-built maps deployed on the remote server, which can robustly run in real-time on a mobile device even in high latency situations. By tightly coupling VIO with geometric priors from pre-built maps, our system can tolerate the high latency and low frequency of global localization service, which is especially suitable for practical applications when the localization service is deployed on the remote server. Firstly, sparse point clouds are obtained from the dense mesh by the ray casting method according to the localization results. The dense mesh can be reconstructed from the point clouds generated by Structure-from-Motion. We directly use the sparse point clouds in feature tracking and state update to suppress drift. In the process of feature tracking, the high local accuracy of VIO is fully utilized to effectively remove outliers and make our system robust. The experiments on EurocMav datasets and simulation datasets show that compared with state-of-the-art methods, our method can achieve better results in terms of both precision and robustness. The effectiveness of the proposed method is further demonstrated through a real-time AR demo on a mobile phone with the aid of visual localization on the remote server.

[An experimental study on prevention of peridural adhesion after laminectomy].

OBJECTIVE: To explore effective substances and methods for prevention of peridural adhesion. METHODS: Laminectomy was performed on the 5th lumbar segment in 64 rabbits, which were equally divided into 4 groups. The dura mater (12 mm x 6 mm) was exposed. The exposed dura mater was left uncovered in Group A; the exposed dura mater was covered with sodium hyaluronate jel (high molecular weight, 1 ml) in Group B; the lamina repair was performed with the autologous spinous process in Group C; the lamina repair was performed with the sodium hyaluronate jel filling and the autologous spinous process in Group D. The specimens were observed grossly and histologically at 2, 4, 6 and 8 weeks postoperatively. The computed imaging analysis on the epidural adhesion was also performed at 6 weeks postoperatively. RESULTS: 1) The gross anatomical evaluation: Severe peridural adhesion was formed in Group A, less adhesion formed in Groups B and C, but no obvious adhesion formed in Group D. 2) The area percentage of the epidural scar: The area percentage of the epidural scar was 15.89%+/-1.88% and 13.94%+/-1.89% in Groups C and D respectively, which were significantly lower than those in Groups A and B (22.66%+/-2.89% and 20.70%+/-2.82%, P<0. 05). 3) The density of epidural scar: The density of the epidural scars were 42.03%+/-7.36% and 36. 50+/-9.08% in Groups B and D, which were significantly lower than those in Groups A and C (63.73%+/-6.06% and 52. 11%+/- 4.10%, P< 0.05). CONCLUSION: The high molecular weight sodium hyaluronate jel filling combined with the lamina repair using the autologous spinous process has the best preventive effect on the peridural adhesion after laminectomy.