ABSTRACT
Water evaporation is a ubiquitous and spontaneous phase transition process. The utilization of solar-driven interface water evaporation that simultaneously obtains clean water and power generation can effectively alleviate people's concerns about fresh water and energy shortages. However, it remains a great challenge to efficiently integrate the required functions into the same device to reduce the complexity of the system and alleviate its dependence on solar energy to achieve full-time operation. In this work, a multifunctional device based on reduced graphene oxide (RGO)/Mn3 O4 /Al2 O3 composite nanomaterials is realized by an asymmetric strategy for effective solar-thermal-electro integration that can induce power generation by water evaporation in the presence/absence of light. Under one sun irradiation, the solar-driven evaporation rate and output voltage are 1.74 kg m-2 h-1 and 0.778 V, respectively. More strikingly, the nine-grid evaporation/power generation array integrated with multiple devices in series has the advantages of small volume, large evaporation area, and high power generation, and can light up light-emitting diodes (LEDs), providing the possibility for large-scale production and application. Based on the high photothermal conversion efficiency and power production capacity of the RGO/Mn3 O4 /Al2 O3 composite evaporation/generator, it will be a promising energy conversion device for future sustainable energy development and applications.
ABSTRACT
A new caffeic acid tetramer compound, named (+) methyl rabdosiin (4), together with seven known caffeic acid multimers (1-3, 5-8) and one caffeic acid monomer (9), were isolated from the aerial parts of Dracocephalum moldavica L. The structures of these compounds were assigned on the basis of 1D and 2D NMR spectroscopic and mass spectrometry analyses. The protective effects of compounds 2-4 against hydrogen peroxide (H2O2)-induced apoptosis were evaluated in primary cardiomyocytes of SD neonatal rats in vitro by the MTT method. Three compounds exhibited potent protective activities at 12.5 µg/mL.
Subject(s)
Caffeic Acids/isolation & purification , Lamiaceae/chemistry , Lignans/isolation & purification , Plant Extracts/chemistry , Protective Agents/isolation & purification , Animals , Apoptosis/drug effects , Caffeic Acids/analysis , Cells, Cultured , Hydrogen Peroxide/toxicity , Lignans/analysis , Molecular Structure , Myocytes, Cardiac/drug effects , Myocytes, Cardiac/pathology , Protective Agents/pharmacology , Rats , Spectrum AnalysisABSTRACT
Synchronous gastric tumors that consist of both gastrointestinal stromal tumor (GIST) and adenocarcinoma are rare. We studied the clinicopathological and molecular characteristics of six cases containing both gastric adenocarcinoma and GIST. By means of immunohistochemical analysis, all GIST cells expressed CD117, CD34 and Dog1 in all six synchronous gastric adenocarcinomas with GIST, and in GIST alone. Sequencing analysis demonstrated that exon 11 c-kit mutations were present in two of six synchronous tumors and four of five GISTs. One of the two exon 11 c-kit mutations in synchronous adenocarcinomas with GISTs was an uncommon mutation of CTT > CCA at amino acid 576, and the other was a GTT deletion at amino acid 560. The mutation was a homozygous A > G mutation in exon 12 (amino acid 567) of PDGFR-α. We concluded that the exon 11 mutations were the most important in both cases of synchronous gastric adenocarcinoma with GIST and GIST alone. The mutation rate was higher in GIST alone than in synchronous adenocarcinoma with GIST.
Subject(s)
Adenocarcinoma/genetics , Adenocarcinoma/pathology , Gastrointestinal Stromal Tumors/genetics , Gastrointestinal Stromal Tumors/pathology , Neoplasms, Multiple Primary/genetics , Neoplasms, Multiple Primary/pathology , Stomach Neoplasms/genetics , Stomach Neoplasms/pathology , Aged , Base Sequence , DNA, Neoplasm/genetics , Female , Humans , Male , Middle Aged , Mutation/genetics , OncogenesABSTRACT
A diode-pumped nanosecond eight-pass amplifier with Nd:YVO4 crystal was developed. Combined with the advantages of direct pumped and Innoslab structure, a high energy pulse was obtained by using the wedged multi-folded configuration with two plane mirrors. The 0.4mJ Q-switched seed at the pulse repetition frequency of 10kHz was amplified to 8.4mJ with the pump power of 330W, and the corresponding optical-to-optical efficiency was 29.8%. The M2 factors in the horizontal direction and vertical direction were 1.48 and 1.39, respectively. And no remarkable of ASE was observed.
ABSTRACT
Polymerized porcine hemoglobin (pPolyHb), which was synthesized from chemically modified porcine hemoglobin, can carry and deliver oxygen to tissues in addition to restoring intravascular volume. Assessment of the inflammatory response generated in the host is a part of the overall safety evaluation of pPolyHb. In this study, we measured the levels of IL-1ß, IL-10, and CD11b/CD18 in response to pPolyHb stimulation, both in vivo (in rats) and in vitro. Our results suggest that the levels of these indicators are not statistically changed by pPolyHb, indicating that pPolyHb is not immunotoxic to cells and animals in this respect.
Subject(s)
Hemoglobins/adverse effects , Neutrophils/drug effects , Safety , Swine , Animals , CD11b Antigen/metabolism , CD18 Antigens/metabolism , Female , Gene Expression Regulation/drug effects , Gene Expression Regulation/immunology , Interleukin-10/metabolism , Interleukin-1beta/metabolism , Male , Mice , Neutrophils/metabolism , Rats , Shock, Hemorrhagic/immunologyABSTRACT
Small bowel transplantation (SBTx) has become a standard clinical treatment for short bowel syndrome or irreversible intestinal function failure. Optimum preservation of the organ is essential for the success of transplantation. In this study, pPolyHb was used as an additive to hypertonic citrate adenine solution (HCA) to provide oxygen for rat small bowel transplant. Rat small bowels were preserved in HCA, HCA with pPolyHb, and University of Wisconsin solution (UW) for 12, 24, and 36 h, respectively. The results suggested that the preservation effect of HCA with pPolyHb was comparable with the UW solution, and more effective than the HCA solution.
Subject(s)
Hemoglobins/chemistry , Intestine, Small , Preservation, Biological/methods , Protein Multimerization , Adenine/pharmacology , Adenosine Triphosphate/metabolism , Animals , Blood Gas Analysis , Intestine, Small/cytology , Intestine, Small/drug effects , Intestine, Small/metabolism , Male , Rats , SwineABSTRACT
We demonstrated a laser-diode, end-pumped picosecond amplifier. With effective shaping of the seed laser, we achieved 73 W amplified laser output at the pump power of 255 W, and the optical-optical efficiency was about 28%. The beam propagation factors M(2) measured at the output power of 60 W in the horizontal direction and the vertical direction were 1.5 and 1.4, respectively.
ABSTRACT
We demonstrate a high-power laser diode stacks double-end-pumped Nd:YVO4 1064 nm slab laser with a folded stable-unstable hybrid resonator. An output power of 220 W was obtained at the pump power of 490 W with optical conversion efficiency of 44.9%. At the output power of 202 W, the M2 factors in the unstable direction and in the stable direction were 1.7 and 2.3, respectively.
ABSTRACT
We utilize a sliced slab waveguide structure to produce a gain waveguide array. With this array, an in-phase locked single-mode frequency output with a single-peak intensity distribution without sidelobes and a highly spatially suppressed far-field distribution has been obtained.
ABSTRACT
A diode stack end-pumped Nd:YVO4 slab laser at 1342 nm with near-diffraction-limited beam quality by using a hybrid resonator was presented. At a pump power of 139.5 W, laser power of 35.4 W was obtained with a conversion efficiency of 25.4% of the laser diode to laser output. The beam quality M2 factors were measured to be 1.2 in the unstable direction and 1.3 in the stable direction at the output power of 29 W.
