ABSTRACT
Herein, we report an iodine-attached Zn(II)-porphyrinic dicarboxylic building block (ZnDTPP-I2-2H, 1) that can be introduced into UiO-66 NMOF via one-pot synthetic approach to generate a new ZnDTPP-I2 doped UiO-66 type nano metal-organic framework (NMOF) of ZnDTPP-I2âUiO-66 (2). Compared to its homologous iodine-free NMOF of ZnDTPPâUiO-66 (4), ZnDTPP-I2âUiO-66 (2) with heavy iodine atoms is a more effective nanosized photosensitizer for singlet oxygen generation under physiological conditions. As expected, 2 displayed a high photodynamic therapy efficacy for treatment of liver cancer cells in vitro.
Subject(s)
Metal-Organic Frameworks/pharmacology , Metalloporphyrins/pharmacology , Photochemotherapy , Photosensitizing Agents/pharmacology , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Antineoplastic Agents/radiation effects , Drug Stability , Hep G2 Cells , Humans , Light , Luminescence , Metal-Organic Frameworks/chemical synthesis , Metal-Organic Frameworks/chemistry , Metal-Organic Frameworks/radiation effects , Metalloporphyrins/chemical synthesis , Metalloporphyrins/chemistry , Metalloporphyrins/radiation effects , Nanoparticles/chemistry , Nanoparticles/radiation effects , Photosensitizing Agents/chemical synthesis , Photosensitizing Agents/chemistry , Photosensitizing Agents/radiation effects , Singlet Oxygen/chemistry , Zinc/chemistry , Zirconium/chemistryABSTRACT
Condensation of benzene-1,3,5-tricarbohydrazide with benzene-1,4-dicarboxaldehyde generated a new covalent organic framework, COF-ASB (1), in which the organic units are held together via hydrazone linkage to form porous frameworks. COF-ASB (1) is highly crystalline and displays good chemical and thermal stability and is permanently porous. In addition, 1 can be an ideal support to load Ru nanoparticles (Ru NPs) to generate Ru@COF-ASB (2). The obtained composite material is able to highly promote one-pot tandem synthesis of imine products from benzyl alcohols and corresponding amines under solvent-free conditions in air.