A critical review of presence, removal and potential impacts of endocrine disruptors bisphenol A.

Bisphenol A (BPA) is a synthetic organic compound that is mainly used in the production of polymer materials polycarbonate and epoxy resin. Widespread use and irregular processing methods have led to BPA being detected globally, raising concerns about its environmental and health effects. This review outlines an overview of the presence and removal of BPA in the environment and consumer products. We also summarized the endocrine-disrupting toxicity of BPA, and the relatively less summarized neurotoxicity, cytotoxicity, reproductive toxicity, genotoxicity, and carcinogenicity. Human exposure data show that humans have been exposed to low concentrations of BPA for a long time, future research should focus on the long-term exposure and the migration of BPA from consumer products to humans and the possible health risks associated with human exposure to BPA. Exploring economical and effective methods to reduce and remove BPA from the environment is imperative. The development of safe, functional and reproducible BPA analogs and the study of its degradation products can be the focus of subsequent research.

Investigating the toxically homogenous effects of three lanthanides on zebrafish.

The adverse effects of rare earth elements (REEs) have been increasingly reported in the past decades and have raised concern about their environmental toxicities. However, the available data is insufficient to elucidate the toxic effects, mechanisms, and whether the toxicity across all REEs is uniform. In this study, zebrafish were exposed to 0, 0.8, 1.6, 3.2, 6.4, 12.8 and 25.6 mg/L Ln(NO3)3•6H2O to test the acute toxicity of La(III), Ce(III), and Nd(III). LC50 of the three lanthanides was compared to the extent of the impact on gene expression. We carried out the functionally grouped network-based transcriptome analysis using gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) to explore the molecular mechanisms. The acute toxicity test showed that LC50 of La(III), Ce(III), and Nd(III) were 2.53, 2.03, and 2.76 mg/L, respectively. Consistent with acute toxicity, Ce(III) caused a little more DEGs than La(III) and Nd(III). Some biological processes such as metabolism of xenobiotics, oocyte meiosis, steroid biosynthesis, DNA replication, and p53 signaling pathway were affected following exposure of all the three lanthanides. Ce(III) also induced changes in the chemokine-mediated signaling pathway. The results indicated that the lethality is comparable, and the toxic patterns are similar across the three lanthanides. This study gives comparative research on the toxicities of three lanthanides to model organism zebrafish.

Empirical Study on the Impact of Urban and Rural Resident Basic Medical Insurance on Children's Educational Outcomes.

This paper employs data from the 2016 and 2018 China Family Panel Studies (CFPS) to study the impact of participation in Urban and Rural Resident Basic Medical Insurance (URRBMI) on children's educational outcomes by using the logit model, double selection Lasso model, and propensity score matching. It is found that participating in URRBMI has no significant effect on children's Chinese performance, but has a significant negative effect on children's mathematics performance. The negative effect is more obvious for children who participating in the New Cooperative Medical Scheme (NCMS). The paper also studies the channel effects of participation in URRBMI on children's educational outcomes trough two different ways. It is noticed that both channel effects are not significant, that is, participation in URRBMI neither improves children's health nor changes household education expenditures.

Heterogeneous Effects of Health Insurance on Rural Children's Health in China: A Causal Machine Learning Approach.

This paper investigates the impact of Urban and Rural Resident Basic Medical Insurance (URRBMI) on the health of preschool and school-age children in rural China using data from the 2018 wave of the China Family Panel Studies (CFPS). We employ the propensity score matching approach and causal forest to evaluate impacts. Results show that the URRBMI has significantly improved the health status of preschool children. However, the health improvement of school-age children by URRBMI is only limited to obese children, and this effect is not significant. In addition, this paper identifies important variables related to heterogeneity through the causal forest and evaluates the heterogeneity of the impact of URRBMI on the health of two types of children. For preschool children, we find disadvantaged mothers (i.e., with lower wealth, lower educated, or in rural areas) benefit more from the URRBMI. No significant heterogeneity is found for the school-age children. Our study demonstrates the power of causal forest to uncover the heterogeneity in policy evaluation, hence providing policymakers with valuable information for policy design.