Relationship between parental reproductive age and the risk of overweight and obesity in offspring / 中华预防医学杂志

Objective: To explore the role of parental reproductive age on the risk of overweight and obesity in offspring. Methods: The participants were derived from physical examination data of students aged 6-18 years in seven provinces in China, and questionnaire survey was used to collect demographic characteristics and lifestyle information of the students and their parents. A total of 41 567 children with complete data were included. According to the restricted cubic spline curve, maternal reproductive age was divided into three categories, 14-23, 24-28, and 29-38 years, and paternal reproductive age was divided into 14-23, 24-30, and 31-42 years. Multivariate logistic regression model was used to analyze the association between parental reproductive age and parental nutritional status and the risk of overweight and obesity in offspring. Results: The mean age of 41 567 children was (10.6±3.2) years, and the mean paternal and maternal age were (27.9±4.4) years and (25.8±4.0) years, respectively. The detection rate of overweight and obesity was 23.4%. After adjusting factors of children diet and behaviors, the OR(95%CI)of offspring overweight and obesity in groups of fathers aged 24-30 years and mothers aged 24-28 years was 1.11 (1.04-1.18) and 1.16 (1.08-1.24), respectively. When none parents were overweight and obese, the difference of obesity risk was not statistically significant. When both parents were overweight and obese, the OR(95%CI)of offspring overweight and obesity in groups of fathers aged 24-30 years and mothers aged 14-28 years old was 1.27 (1.00-1.62) and 1.33 (1.07-1.65) respectively. Conclusion: Parental reproductive age and parental overweight and obesity status may both increase the risk of overweight and obesity in offspring, with a significant interaction effect.

The role of ethnicity versus environment in tear film stability: A pilot study.

PURPOSE: Existing literatures suggest a difference in tear film stability between Caucasian and Asian ethnic groups. However, such a finding was compounded by the fact that the comparison was done on subjects living in different environments. Therefore, it is not clear whether such difference is due to ethnicity, environment, or both. The aim of this study is to clarify the roles of these two factors. METHODS: A total of 88 asymptomatic subjects participated in this present study. For each subject, the tear film break-up time (TBUT), non-invasive TBUT (NITBUT) and tear meniscus height (TMH) were measured. To isolate the effect of ethnicity, the results of 12 American Asian young adults were compared against the results of 23 Caucasian adults. Both groups were recruited from Nova Southeastern University. To elucidate the effect of environment, the results from the same 12 American Asians were compared to that of the 53 Asian young adults recruited from the Tianjin Vocational Institute, China (Tianjin Asian). RESULTS: The tear film stability did not show significant difference among American Asian subjects and Caucasian subjects in TBUT (10.49 ± 2.86 s vs. 11.06 ± 2.79 s,p = 0.57), NITBUT (11.19 ± 4.89 s vs. 11.14 ± 6.20 s, p = 0.98), and TMH (0.21 ± 0.08 mm vs. 0.22 ± 0.05 mm, p =0.59). However, the tear film stability was significantly better in the American Asian group than the Tianjin Asian group in TBUT (10.49 ± 2.86 s vs. 7.60 ± 3.26 s, p = 0.01), NITBUT (11.19 ± 4.89 s vs. 8.03 ± 3.56 s, p = 0.01), and TMH (0.21 ± 0.08 mm vs. 0.14 ± 0.03 mm, p < 0.01). CONCLUSIONS: The previously reported difference in Caucasian and Asian populations might be due to the fact that the studied subjects have different living environments.