Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study.

BACKGROUND: Bone marrow lesions (BMLs) are a common finding in patients with osteoarthritis (OA), which are predictors of progression and pain related to cartilage damage in OA. The objective of the present research was to compare the short-term clinical effect of intramuscular calcitonin and oral celecoxib in treating knee BMLs. PATIENTS AND METHODS: Between January 2016 and December 2018, the medical records of patients with knee BMLs treated by intramuscular calcitonin or oral celecoxib were reviewed. Visual analog scale (VAS) and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) were used to assess knee pain and function, respectively. BMLs were assessed by MRI scans and were scored by the modified Whole-Organ MRI Score (WORMS). The safety of these two medications was also evaluated. RESULTS: A total of 123 eligible patients who received calcitonin treatment (n = 66) or celecoxib treatment (n = 57) were included. All patients were followed up clinically and radiographically for 3 months. The VAS and WOMAC scores were lower statistically in calcitonin group than celecoxib group at 4-week and 3-month follow-up. For BMLs, the WORMS scores in the calcitonin group were significantly lower than the celecoxib group. Besides, statistically higher MRI improvement rates were found in the calcitonin group compared with the celecoxib group at 4-week follow-up (21.21% vs. 7.01%; P = 0.039) and 3-month follow-up (37.88% vs. 15.79%; P = 0.006). CONCLUSION: Intramuscular calcitonin 50 IU once daily demonstrated a better short-term effect for knee BML patients compared with oral celecoxib 200 mg twice per day.

Incidence of Surgical Site Infection After Spine Surgery: A Systematic Review and Meta-analysis.

STUDY DESIGN: A systematic review and meta-analysis. OBJECTIVE: The objective of this study was to investigate the incidence of surgical site infection (SSI) in patients following spine surgery and the rate of microorganisms in these cases. SUMMARY OF BACKGROUND DATA: Many studies have investigated the incidence and risk factors of SSI following spinal surgery, whereas no meta-analysis studies have been conducted regarding the comprehensive epidemiological incidence of SSI after spine surgery. METHODS: We searched the PubMed, Embase, and Cochrane Library databases for relevant studies that reported the incidence of SSI after spine surgery, and manually screened reference lists for additional studies. Relevant incidence estimates were calculated. Subgroup analysis, sensitivity analysis, and publication bias assessment were also performed. RESULTS: Our meta-analysis included 27 studies, with 603 SSI cases in 22,475 patients. The pooled SSI incidence was 3.1%. Subgroup analysis revealed that the incidence of superficial SSI was 1.4% and the incidence of deep SSI was 1.7%. Highest incidence (13.0%) was found in patients with neuromuscular scoliosis among the different indications. The incidences of SSI in cervical, thoracic, and lumbar spine were 3.4%, 3.7%, and 2.7%, respectively. Compared with posterior approach surgery (5.0%), anterior approach showed a lower incidence (2.3%) of SSI. Instrumented surgery had a higher incidence of SSI than noninstrumented surgery (4.4% vs. 1.4%). Patients with minimally invasive surgery (1.5%) had a lower SSI incidence than open surgery (3.8%). Lower incidence of SSI was found when vancomycin powder was applied locally during the surgery (1.9%) compared with those not used (4.8%). In addition, the rates of Staphylococcus aureus, Staphylococcus epidermidis, and methicillin-resistant Staphylococci in microbiological culture results were 37.9%, 22.7%, and 23.1%, respectively. CONCLUSION: The pooled incidence of SSI following spine surgery was 3.1%. These figures may be useful in the estimation of the probability of SSI following spine surgery. LEVEL OF EVIDENCE: 3.

0.5- to 1-Fold Intervertebral Distraction Is a Protective Factor for Adjacent Segment Degeneration in Single-level Anterior Cervical Discectomy and Fusion.

STUDY DESIGN: Retrospective analysis. OBJECTIVE: This study aimed to compare the clinical and radiological outcomes of different degrees of distraction in anterior cervical discectomy and fusion (ACDF) and evaluate the risk factors for adjacent segment degeneration (ASD). SUMMARY OF BACKGROUND DATA: ASD is a common complication following ACDF. Inadequate distraction of the intervertebral space during surgery is associated with ASD; however, there is still an ongoing debate regarding what degree of distraction is appropriate. METHODS: This retrospective study enrolled 130 patients who underwent single-level ACDF for cervical degenerative disc disease and were followed up at least 2 years. The patients were divided into the following three groups according to the degree of distraction (≤0.5, 0.5-1, ≥1): insufficient distraction group (ID group), appropriate distraction group (AD group), and excessive distraction group (ED group). The clinical outcomes and radiological parameters were evaluated before and after operation and at the last follow-up. Risk factors for ASD were identified through logistic regression analysis. RESULTS: A significant difference was found in the Visual Analog Scale values between the AD group and ED group at the final follow-up. Moreover, the highest upper segmental disc height (DH), highest lower segmental DH, and lowest incidence of ASD were found in the AD group among the three groups at last follow up. Logistic regression analysis revealed that segmental kyphosis (odds ratio = 2.821, P = 0.020) was a risk factor for the occurrence of ASD and 0.5- to 1-fold distraction (odds ratio = 0.350, P = 0.025) was a protective factor. CONCLUSION: Good clinical and radiological outcomes were achieved in ACDF with 0.5- to 1-fold distraction. Segmental kyphosis is a risk factor for ASD in ACDF, whereas 0.5- to 1-fold distraction is a protective factor of ASD. LEVEL OF EVIDENCE: 4.

Functional Connectivity Changes of the Visual Cortex in the Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study.

STUDY DESIGN: Cross-sectional study. OBJECTIVE: To analyze altered functional connectivity (FC) in the visual cortex of cervical spondylotic myelopathy (CSM) patients using resting-state functional magnetic resonance imaging (fMRI). SUMMARY OF BACKGROUND DATA: We previously showed changes in visual cortex neural activity in CSM patients. METHODS: Thirty CSM patients and 20 healthy controls were recruited. MR data were collected using a 3.0 T MR. FC of the regions of interest (ROI) (Brodmann areas [BA] 17/18/19/7) were calculated in a voxel-wise manner and compared between groups. Correlation analyses were performed between preoperative Japanese Orthopaedic Association (JOA) scores and altered FC, as well as between preoperative best corrected visual acuity (BCVA) and altered FC. Furthermore, the FC where was compared between the preoperative and the postoperative CSM patients in an ROI-wise manner. RESULTS: Increased FC was found between BA19 and the cerebellum inferior lobe; between the left BA7 and bilateral calcarine, right lingual, right fusiform gyrus, and left precuneus (BA17); between the left BA7 and right fusiform gyrus and right inferior occipital gyrus (right BA19); and between the right BA7 and right superior lobe of cerebellum (right BA19) in CSM patients (P < 0.05). A negative correlation was found between JOA score and FC of the left and right BA19, and a positive correlation was found between the BCVA and FC of the left and right BA7 (P < 0.05). ROI analysis demonstrated statistically significant FC differences in between the preoperative and the postoperative CSM patients (P < 0.05). CONCLUSION: FC changes were present in the visual cortex of CSM patients, which negatively correlated with preoperative JOA scores and positively correlated with preoperative BCVA. Significant recovery of FC in the visual cortex was detected in CSM patients postoperatively. LEVEL OF EVIDENCE: 4.

Visual cortex neural activity alteration in cervical spondylotic myelopathy patients: a resting-state fMRI study.

PURPOSE: We sought to investigate visual cortex neural activity and functional connectivity (FC) alterations in cervical spondylotic myelopathy (CSM) patients using resting-state fMRI (rs-fMRI) and to explore the relationships of these alterations with visual disorder. METHODS: Twenty-seven CSM patients and 11 healthy controls were recruited as the study and control groups. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) values were calculated to represent neural activity, seed-based correlation analysis (SCA) was performed to analyze the FC of visual cortex, and the outcomes were compared between groups. The preoperative best-corrected visual acuity (pre-BCVA) and postoperative BCVA (post-BCVA) of study groups were measured. Correlation analyses of the ALFF/ReHo values with the preoperative and postoperative BCVAs were performed. Correlations of the bilateral BCVAs with the ipsilateral and contralateral visual cortex neural activities were performed. RESULTS: The ALFF/ReHo values were decreased in the occipital lobe and increased in the cerebellar posterior lobe in the study group (P < 0.05). Increased FC was demonstrated between Brodmann's area 17 and posterior cingulate lobe (P < 0.05). Postoperatively, the BCVAs were ameliorated in 22 oculi dexter (ODs) and 20 oculi sinister (OSs) in the study group. Positive correlations between neural activity in the visual cortex and the preoperative and postoperative BCVAs were detected in the study group. The bilateral BCVAs were positively correlated with either the ipsilateral or contralateral visual cortex neural activity. CONCLUSION: Both ALFF/ReHo value changes and positive correlations of these changes with BCVA were demonstrated in CSM. The FC between the visual cortex and posterior cingulate lobe was also increased in CSM.