ABSTRACT
Conflicting results to identify the relationship between tooth loss and cancer risk. Therefore, a dose-response meta-analysis was performed to clarify and quantitative assessed the correlation between tooth loss and cancer risk. Up to March 2017, 25 observational epidemiological studies were included in current meta-analysis. Tooth loss was significantly associated with a higher risk of cancer. Additionally, tooth loss was associated with significantly a higher risk of esophageal cancer, gastric cancer, head and neck cancer, colorectal cancer, pancreas cancer, lung cancer, prostate cancer, bladder cancer and hematopoietic cancer. Subgroup analysis showed consistent findings. Furthermore, a significant dose-response relationship was observed between tooth loss and cancer risk. Increasing per 10 of tooth loss was associated with a 9% increment of cancer risk, 14% increment of esophageal cancer risk, 9% increment of gastric cancer risk, 31% increment of head and neck cancer risk, 4% increment of colorectal cancer risk, 7% increment of pancreas cancer risk, 19% increment of lung cancer risk, 2% increment of bladder cancer risk and 3% increment of hematopoietic cancer risk. Considering these promising results, tooth loss might be harmful for health. Large sample size, different ethnic population and different cancer type are warranted to validate this association.
ABSTRACT
Conflicting results identifying the relationship between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk. Therefore, we performed this meta-analysis to clarify and quantitative assessed the relationship between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk. Up to March 2017, 11 original publications were included in this meta-analysis. Our results showed statistically significant association between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk reduction. Subgroups analysis indicated that Aspirin, COX 2 inhibitors, Ibuprofen and Other NSAIDs were associated with a significantly risk reduction of head and neck cancer. Furthermore, nonsteroidal anti-inflammatory drugs using was associated with a significantly lower risk of oral and oropharynx cancer, larynx cancer and hypopharynx cancer. In addition, increasing nonsteroidal anti-inflammatory drugs using (per 2 prescriptions/week increment) was associated with a 4% reduction in head and neck cancer risk, 5% reduction of aspirin using and 6% reduction of other nonsteroidal anti-inflammatory drugs using. Considering these promising results, increasing nonsteroidal anti-inflammatory drugs using might provide health benefits. More studies and large sample size are warranted to validate this association.
ABSTRACT
OBJECTIVE: To explore the morphological basis of electroacupuncture (EA) in relieving addiction of ketamine. METHODS: Forty Sprague-Dawley rats were randomized into normal control, normal saline (10 mL/kg), model and ketamine+ EA groups. Ketamine-addiction model was established by intraperitoneal administration of ketamine (100 mg/kg) , once a day for 7 days. EA (2 Hz) was applied to "Zusanli" (ST 36) and "Sanyinjiao"(SP 6) for 30 min, once a day for 7 days. The expression of tyrosine hydroxylase (TH) and c-fos in the hippocampal CA 1 region was detected by immunohistochemistry. RESULTS: In comparison with the normal control group and normal saline group, the numbers of both TH immune-reaction (IR)-positive and c-fos IR-positive neurons in the hippocampal region in the model group were increased significantly (P<0. 05, P<0. 01). Correspondingly, the expression of both TH IR-positive and c-fos IR-positive products in the hippocampal CA 1 region in the model group was upregulated evidently (P<0. 05, P<0. 01). After EA of "Zusanli" (ST 36)-"Sanyinjiao" (SP 6), compared with the model group, the expression of both TH IR-positive and c-fos IR-positive products was downregulated considerably (P<0. 01). CONCLUSION: EA of "Zusanli"(ST 36)-"Sanyinjiao" (SP 6) can downregulate ketamine-addiction induced increase of expression of tyrosine hydroxylase and c-fos in the hippocampal CA 1 region in ketamine-addiction rats, which may contribute to its effect in relieving ketamine addiction symptoms in clinic.
