Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Chem Commun (Camb) ; 56(24): 3567-3570, 2020 Mar 24.
Article in English | MEDLINE | ID: mdl-32104795

ABSTRACT

Fluorescent small molecules are powerful tools for imaging α-synuclein pathology in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small molecule binding sites.


Subject(s)
Benzofurans/chemistry , Fluorescent Dyes/chemistry , alpha-Synuclein/analysis , Alzheimer Disease , Fluorescence , Humans , Microscopy, Fluorescence , Multiple System Atrophy , Parkinson Disease
SELECTION OF CITATIONS
SEARCH DETAIL
...