ABSTRACT
This experiment aimed to explore the influence mechanism of external fixator on open fracture. A total of 128 patients with open tibiofibular fractures were included in this study. The patients were randomly divided into external fixator group (n=64) and control group (n=64) according to the order of admission. Double-blind controlled observation was used. The levels of osteocalcin (BGP), ß-CTX, P1 NP, BALP, including haptoglobin (Hp), ceruloplasmin (CER), serum adrenocorticotropic hormone (ACTH), cortisol (COR), C-reactive protein (CRP), white blood cell (WBC) and interleukin-6 (IL-6) were recorded in different groups. The postoperative VAS score and quality of life were recorded. Log-rank was used to analyze the difference in postoperative adverse reaction rates among different groups. External fixation stent treatment increased BGP, PINP, and BALP expression and decreased ß-CTX, Hp, CER, ACTH, COR, CRP, WBC, and IL-6 levels. Patients in the external fixation stent group had significantly lower VAS score quality of life scores and incidence of adverse events than the control group. External fixation stents protect open fracture patients by promoting bone metabolism.
Subject(s)
Bone and Bones , C-Reactive Protein , External Fixators , Osteocalcin , Quality of Life , Humans , Male , Female , Adult , Osteocalcin/blood , Osteocalcin/metabolism , Middle Aged , Bone and Bones/metabolism , C-Reactive Protein/metabolism , Fractures, Open/surgery , Fractures, Open/metabolism , Interleukin-6/blood , Interleukin-6/metabolism , Procollagen/blood , Procollagen/metabolism , Double-Blind Method , Collagen Type I/metabolism , Collagen Type I/blood , Adrenocorticotropic Hormone/blood , Adrenocorticotropic Hormone/metabolism , Peptide Fragments/blood , Extremities/surgery , Extremities/injuries , Peptides , Hydrocortisone/bloodABSTRACT
OBJECTIVE: To examine the basic biomechanics of locking plate fixation plus calcium phosphate bone cement (CPC) for unstable intertrochanteric fractures. METHODS: A total of 18 Chinese fresh femur specimens without pathological defects, fractures, malformations or neoplasms were collected. In accordance with the Evans classification of IIIA type, the intertrochanteric fracture model was established. There were 18 femoral samples in each group. The experimental group received locking plate (LPFP) fixation plus CPC while the control group had a simple LPFP fixation. The mechanical tests were performed. RESULTS: Under different load-strain conditions, the results were as follows: 600 kg · m · s(-2) experimental group 98 + 3.6 vs control group 127 + 4.4 µÎµ; 3000 kg · m · s(-2) experimental group 278 + 23 vs control group 457 + 45 µÎµ. And under different load-displacement conditions, 500 kg · m · s(-2) experimental group 0.16 + 0.02 vs control group 0.23 + 0.04 mm; 4000 kg · m · s(-2) experimental group 2.79 ± 0.59 vs control group 5.05 + 0.68 mm. The torsional mechanical 0.1 (°/cm) properties: experimental group 0.14 + 0.01 vs control group 0.23 + 0.04 (kg · m · s(-2) · m); 0.8 (°/cm) experimental group 3.14 + 0.17 vs control group 2.57 (kg · m · s(-2) · m) + 0.08 (kg · m · s(-2) · m) (P < 0.05). CONCLUSION: The combined regimen of locking plate fixation and calcium phosphate cement offers remarkable advantages over simple locking plate fixation in its excellent anti-compression and anti-torsion performances in the treatment of unstable intertrochanteric fractures. With a reasonable design, it has a greater stability.
