Anisotropic Semicrystalline Homopolymer Dielectrics for High-Temperature Capacitive Energy Storage.

High-temperature dielectric polymers are in high demand for powering applications in extreme environments. Here, we have developed high-temperature homopolymer dielectrics with anisotropy by leveraging the hierarchical structure in semicrystalline polymers. The lamellae have been aligned parallel to the surface in the dielectric films. This structural arrangement resembles the horizontal alignment of nanosheet fillers in polymer nanocomposites and nanosheet-like lamellae in block copolymers, which has been proven to provide the optimal topological structure for electrical energy storage. The unique ordering of lamellae in our dielectric films endue a significantly increased breakdown strength and a reduced leakage current compared to amorphous films. This novel approach of enhancing the capacitive energy storage properties by controlled orientation of lamellae in homopolymer offers a new perspective for the design of high-temperature polymer dielectrics.

Constructing Novel High Dielectric Constant Polyimides Containing Dipolar Pendant Groups with Enhanced Orientational Polarization.

Polymer dielectrics with high dielectric constant are urgently demanded for potential electrical and pulsed power applications. The design of polymers with side chains containing dipolar groups is considered an effective method for preparing materials with a high dielectric constant and low loss. This study synthesizes and comprehensively compare the dielectric properties of novel polyimides with side chains containing urea (BU-PI), carbamate (BC-PI), and sulfonyl (BS-PI) functional groups. The novel polyimides exhibit relatively high dielectric constant and low dielectric loss values due to the enhanced orientational polarization and suppressed dipole-dipole interactions of dipolar groups. In particular, BU-PI containing urea pendant groups presents the highest dielectric constant of 6.14 and reasonably low dielectric loss value of 0.0097. The strong γ transitions with low activation energies derived from dielectric spectroscopy measurements have been further evaluated to demonstrate the enhanced free rotational motion of urea pendant dipoles. In energy storage applications, BU-PI achieves a discharged energy density of 6.92 J cm-3 and a charge-discharge efficiency above 83% at 500 MV m-1. This study demonstrates that urea group, as dipolar pendant group, can provide polymers with better dielectric properties than the most commonly used sulfonyl groups.

Ultraviolet-Irradiated All-Organic Nanocomposites with Polymer Dots for High-Temperature Capacitive Energy Storage.

Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems. While inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers, the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film processing. Herein, zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone) to form the all-organic polymer composites for high-temperature capacitive energy storage. Upon ultraviolet irradiation, the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures, which significantly reduces the high-field energy loss of the composites at 200 °C. Accordingly, the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm-3 at 200 °C. Along with outstanding cyclic stability of capacitive performance at 200 °C, this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites.

Cephalopod-inspired polymer composites with mechanically tunable infrared properties.

Cephalopods have evolved an all-soft skin that can rapidly display colors for protection, predation, or communication. Development of synthetic analogs to mimic such color-changing abilities in the infrared (IR) region is pivotal to a variety of technologies ranging from soft robotics, flexible displays, dynamic thermoregulatory systems, to adaptive IR disguise platforms. However, the integration of tissue-like mechanical properties and rapid IR modulation ability into smart materials remains challenging. Here, by drawing inspiration from cephalopod skin, we develop an all-soft adaptive IR composite that can dynamically change its IR appearance upon equiaxial stretching. The biomimetic composite is built entirely from soft materials of liquid metal droplets and elastic elastomer, which are analogs of chromatophores and dermal layer of cephalopod skin, respectively. Driven by externally applied strains, the liquid metal inclusions transition between a contracted droplet state with corrugated surface and an expanded platelet state with relatively smooth surface, enabling dynamic variations in the IR reflectance/emissivity of the composite and ultimately resulting in reversible IR adaption. Strain-actuated flexible IR displays and pneumatically-driven soft devices that can dynamically manipulate their IR appearance are demonstrated as examples of the applicability of this material in emerging adaptive soft electronics.

Study on the Shear Resistance Performance of Grouped Stud Connectors.

In order to further investigate the grouped stud effect on the force properties of stud connectors, based on the premise that the correctness of the finite element simulation method, in this paper, a finite element model of grouped stud connectors was developed, and the grouped stud effect and its sensitivity factors were analyzed in order to validate the recommended formula for calculating the shear capacity of grouped stud connectors. Results show that the number of grouped stud rows and stud row spacing have a significant influence on the grouped stud effect, and the unevenness coefficient of grouped stud force is negatively correlated with the number of grouped stud rows as well as the grouped stud row spacing. Grouped stud connectors with commonly used concrete grades greater than C50 and height-to-diameter ratios of greater than 4 in steel-concrete composite structural bridges are insensitive to changes in the concrete strength grades and the length of the studs. The direction of force transmission for grouped stud changes with the change in loading angle and the unevenness coefficient of force for the grouped stud will therefore be reduced. By comparing the results of the 62 existing groups of grouped stud connectors push-out tests, the mean of the tested to calculated value ratio was found to be 1.12, the variance was 0.023, the dispersion was small, and it was shown that the recommended formula has a high degree of accuracy. The results of this paper can be used as a theoretical basis for the study of the shear stress performance of grouped stud connectors.

Computed tomography angiography-based radiomics model to identify high-risk carotid plaques.

Background: Extracranial atherosclerosis is one of the major causes of stroke. Carotid computed tomography angiography (CTA) is a widely used imaging modality that allows detailed assessments of plaque characteristics. This study aimed to develop and test radiomics models of carotid plaques and perivascular adipose tissue (PVAT) to distinguish symptomatic from asymptomatic plaques and compare the diagnostic value between radiomics models and traditional CTA model. Methods: A total of 144 patients with carotid plaques were divided into symptomatic and asymptomatic groups. The traditional CTA model was built by the traditional radiological features of carotid plaques measured on CTA images which were screened by univariate analysis and multivariable logistic regression. We extracted and screened radiomics features from carotid plaques and PVAT. Then, a support vector machine was used for building plaque and PVAT radiomics models, as well as a combined model using traditional CTA features and radiomics features. The diagnostic value between radiomics models and traditional CTA model was compared in identifying symptomatic carotid plaques by Delong method. Results: The area under curve (AUC) values of traditional CTA model were 0.624 and 0.624 for the training and validation groups, respectively. The plaque radiomics model and PVAT radiomics model achieved AUC values of 0.766, 0.740 and 0.759, 0.618 in the two groups, respectively. Meanwhile, the combined model of plaque and PVAT radiomics features and traditional CTA features had AUC values of 0.883 and 0.840 for the training and validation groups, respectively, and the receiver operating characteristic curves of combined model were significantly better than those of traditional CTA model in the training group (P<0.001) and validation group (P=0.029). Conclusions: The combined model of the radiomics features of carotid plaques and PVAT and the traditional CTA features significantly contributes to identifying high-risk carotid plaques compared with traditional CTA model.

Comparison of the imaging and clinical characteristics between Initial and Recurrent Alcoholic Acute Pancreatitis: a retrospective cross-sectional study.

MATERIALS: Patients with alcoholic acute pancreatitis in our hospital were recruited from Jan 2019 to July 2022 and divided into IAAP and RAAP groups. All patients underwent Contrast-Enhanced Computerized Tomography (CECT) or Magnetic Resonance Imaging (MRI) after administration. Imaging manifestations, local complications, severity scores on the Modified CT/MR Severity Index (MCTSI/MMRSI), Extrapancreatic Inflammation on CT/MR (EPIC/M), clinical severity [Bedside Index for Severity in Acute Pancreatitis (BISAP) Acute Physiology and Chronic Health Evaluation (APACHE-II)], and clinical prognosis were compared between the two groups.Results: 166 patients were recruited for this study, including 134 IAAP (male sex 94%) and 32 RAAP patients (male sex 100%). On CECT or MRI, IAAP patients were more likely to develop ascites and Acute Necrosis collection (ANC) than RAAP patients (ascites:87.3%vs56.2%; P = .01; ANC:38%vs18.7%; P < .05). MCTSI/MMRSI and EPIC/M scores were higher in IAAP than in RAAP patients(MCTSI/MMRSI:6.2vs5.2; P < .05; EPIC/M:5.4vs3.8; P < .05).Clinical severity scores (APACHE-II and BISAP), length of stay, and systemic complications [Systemic Inflammatory Response Syndrome (SIRS), respiratory failure] were higher in the IAAP group than in the RAAP group (P < .05). No mortality outcomes were reported in either group while hospitalized.Conclusions: Patients with IAAP had more severe disease than those with RAAP. These results may be helpful for differentiating care paths for IAAP and RAAP, which are essential for management and timely treatment in clinical practice.

Hydrogen Bonding of Aramid Boosts High-Temperature Capacitive Properties of Polyetherimide Blends.

Polyetherimide (PEI) is the state-of-the-art commercial high-temperature polymer dielectric with excellent thermal and chemical stability and relatively high high-temperature capacitive energy storage properties. The rotation of the dipoles in the PEI chains brings the ß-relaxation which seriously increases the leakage current and decreases the charge-discharge efficiency. In this work, hydrogen bonds have been introduced to limit the dipole rotation of PEI by blending aramids [1,4-poly(ether fluoromethyl naphthalene amide), PNFA] into the PEI matrix. By introducing 10 wt % PNFA, the ß-relaxation of the blend has been significantly reduced which could be observed from the dielectric spectrum. To explore the mechanism of limited ß-relaxation, we analyze the hydrogen bonds in the blend films by infrared spectroscopy and found that the maximum content of hydrogen-bonded carbonyl formed between PNFA and PEI chains was 14.3% when the content of PNFA was 30 wt %. The content of hydrogen bonds formed between PNFA and PEI was positively correlated with the energy storage performance of the blends. The maximum discharged energy density with an efficiency above 90% of the blend film with 30 wt % PNFA reaches 4.1 J cm-3 at 150 °C, which is about 350% higher than that of pristine PEI. This work shows that composing hydrogen bonds by the blending method could be a viable strategy for enhancing the high-temperature energy storage performance of polymer dielectrics, which could be achieved by large-scale preparation and has feasible industrial production prospects.

Side-Chain-Type High Dielectric-Constant Dipolar Polyimides with Temperature Resistance.

Innovative dielectric materials with high-temperature resistance and outstanding dielectric properties have attracted tremendous attention in advanced electronical fields. Polyimide(PI) is considered a promising candidate for the modern electronic industry due to its excellent dielectric properties and comprehensive properties. However, the limited-adjustable range of dielectric constant and the difficulty to obtain a high dielectric constant restrict the application of PI as high dielectric materials. Herein, a novel diamine monomer (2,2'-bis((methylsulfonyl)methyl)-[1,1'-biphenyl]-4,4'-diamine (BSBPA)) containing a rigid biphenyl structure and high dipolar sulfonyl pendant groups is designed for high dielectric polyimides. The rigid biphenyl and polar sulfonyl pendant groups can reasonably optimize the molecular structure and orientational polarization of polyimides to improve their dielectric properties and thermal properties. Moreover, the effect of different bridge linkages on the dielectric properties is studied by using the different dianhydrides. Thus, the PI-BSBPA films especially the DSDA-BSBPA film (DSDA: 3,3',4,4'-diphenylsulfonetetracarboxylic dianhydride) achieve great thermal properties (T5%d of 377 °C and Tg of 358 °C) and excellent dielectric properties (6.95 at 1 kHz) along with high discharged energy density of 5.25 J cm-3 and charge-discharge efficiency of 90%. The collaborative control of main-chain and side-chain engineering is effective to endow the polyimides with high-temperature tolerance and high dielectric performance.

Multilayer Dielectric Nanocomposites with Cross-Linked Dielectric Transition Interlayers for High-Temperature Applications.

In energy storage and transportation systems, polymer dielectrics are widely applied in smart grids, electric vehicles, and power conditioning owing to their incomparable power density and high reliability. However, the dielectric constant (ε) and breakdown strength (Eb) normally cannot be increased simultaneously, which results in insufficient discharged energy density especially at high temperatures. In this work, enhanced Eb and high energy density are archived in multilayer polymer nanocomposites by introducing cross-linked dielectric transition layers. Specifically, the sandwiched composite achieves a huge discharge energy density of 4.64 J cm-3 with a charged-discharged efficiency of 84% at 150 °C and 500 MV m-1. The formation of cross-linked dielectric transition layers between layers of the multilayer nanocomposite could effectively restrain the growth of the electrical tree and greatly increase the Eb. This work presents a strategy for designing high-performance multilayered dielectric polymer nanocomposites by introducing cross-linked dielectric transition layers to reduce the loss from interlayer interfaces.

Pea Peptide Supplementation in Conjunction With Resistance Exercise Promotes Gains in Muscle Mass and Strength.

It is generally considered that protein supplementation and resistance exercise significantly increase muscle mass and muscle growth. As the hydrolysis products of proteins, peptides may play the crucial role on muscle growth. In this study, male rats were orally administrated 0.4 g/kg body weight of pea peptide combined with 8 weeks of moderate intensity resistance exercise training. After treatment, the body gains, upper limb grip, muscle thickness, and wet weight of biceps brachii were tested, and the cross-sectional area of biceps brachii muscle fiber and the types of muscle fibers were determined by HE staining, immunofluorescence staining, and lactate dehydrogenase activity, respectively. Western blot analysis was used to investigate the level of growth-signaling pathway-related proteins. The results showed that pea peptide supplementation combined with resistance exercise training significantly increased body weight, upper limb grip, muscle thickness, wet weight of biceps brachii, and cross-sectional area of muscle fiber. Meanwhile, pea peptide supplementation obviously elevated the ratio of fast-twitch fiber (type II) and the expression of muscle growth-signaling pathway-related proteins. In addition, the PP2 oligopeptide in pea peptide with the amino acid sequence of LDLPVL induced a more significant promotion on C2C12 cell growth than other oligopeptides.

PCL scaffold combined with rat tail collagen type I to reduce keratocyte differentiation and prevent corneal stroma fibrosis after injury.

The cornea is one of the major refractive eye components and could be easily injured. An ineffective healing of corneal stromal wound may cause fibrosis and even loss of vision. Therefore, it is pivotal to prevent corneal fibrosis after injury. In this study, a poly (ε-caprolactone) (PCL) microfibrous scaffold infused with rat tail collagen type I was fabricated to obtain a 3D composite material. Physical and biological properties of PCL/collagen scaffold were evaluated, the effect of PCL/collagen scaffold on the proliferation and differentiation of limbal stromal stem cells (LSSCs) were detected in vitro, the differentiation of keratocytes as well as the expression and arrangement of extracellular matrix (ECM) influenced by PCL/collagen scaffold were investigated in vivo. RNA-sequencing on normal and injured corneas was carried out to find out the differential enriched pathways and gene expression. We discovered that the PCL/collagen scaffold simulated the stromal structure with properties that were most similar to the native cornea, the PCL/collagen scaffold exhibited good mechanical and biological properties. We also observed that the PCL/collagen scaffold reduced keratocyte differentiation. Injured corneas treated with PCL/collagen scaffold exhibited more regular collagen distribution and less fibroblasts and myofibroblasts distribution. By RNA-sequencing, we observed that in injured group, ECM-related pathway was enriched and several ECM-related genes were up-regulated. This study provides evidence that application of PCL/collagen scaffold could be a new therapeutic strategy for corneal injury.

Boosting Highly Efficient Hydrocarbon Solvent-Processed All-Polymer-Based Organic Solar Cells by Modulating Thin-Film Morphology.

Many highly efficient all-polymer-based organic solar cells (OSCs) have been achieved owing to material design and device engineering. However, most of them were achieved by using halogenated solvents to process the active layers, being not beneficial to its nature of green energy technology. In this work, we compared chloroform- and toluene-processed PM6:PY-IT-based all-polymer devices with the same blend solution recipe, same film formation speed, and same postcast treatment. The film cast from toluene exhibited weaker crystallinity. For device performance, toluene enabled a better power conversion efficiency (PCE) of 15.51%, outperforming that of chloroform (15.00%), and it is the highest value for non-halogenated solvent-cast all-polymer-based OSCs to date. Toluene's morphology tuning effect was characterized to increase and balance the charge transport and then suppress the exciton recombination and improve the charge extraction, considered to be the reason for efficiency enhancement. Besides, the toluene-cast active layer-based devices showed slightly better photostability than the chloroform-driven ones. This work provided a new direction for building low-toxicity solvent-treated all-polymer OSCs with cutting-edge performance.

Molecular Engineering of High-Performance Aggregation-Induced Emission Photosensitizers to Boost Cancer Theranostics Mediated by Acid-Triggered Nucleus-Targeted Nanovectors.

Phototheranostics involving both fluorescence imaging and photodynamic therapy has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal toward practical applications, ascribed to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory delivery. In this paper, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers with aggregation-induced emission (AIE) features and well tailored nanocarrier systems. The yielded AIE NPs simultaneously exhibit broad absorption in the visible-light region, bright near-infrared fluorescence emission, high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic systems bearing good photostability and appreciable biosecurity perform well in fluorescence imaging-guided photodynamic cancer therapy. This study thus not only extends the application scopes of AIE nanomaterials but also offers useful insights into constructing advanced cancer phototheranostics.

Good Steel Used in the Blade: Well-Tailored Type-I Photosensitizers with Aggregation-Induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy.

Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration of distinctive PDT strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, a precise nuclear targeting PDT protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics is fabricated for the first time. Of the two synthesized AIE PSs, TTFMN is demonstrated to exhibit superior AIE property and stronger type-I reactive oxygen species (ROS) generation efficiency owing to the introduction of tetraphenylethylene and smaller singlet-triplet energy gap, respectively. With the aid of a lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k-poly(ethylene glycol)5k-succinic anhydride-modified TAT, the corresponding TTFMN-loaded nanoparticles accompanied with acid-triggered nuclear targeting peculiarity can quickly accumulate in the tumor site, effectively generate type-I ROS in the nuclear region and significantly suppress the tumor growth under white light irradiation with minimized systematic toxicity. This delicate "Good Steel Used in the Blade" tactic significantly maximizes the PDT efficacy and offers a conceptual while practical paradigm for optimized cancer treatment in further translational medicine.

Anticancer Effect of Biodegradable Magnesium on Hepatobiliary Carcinoma: An In Vitro and In Vivo Study.

Biliary-stent implantation has become an effective treatment for patients with malignant obstructive jaundice caused by hepatobiliary carcinoma. Stent restenosis due to tumor ingrowth is a common problem. In this study, we assessed a biodegradable form of magnesium (Mg) for its anticancer effect on hepatobiliary carcinoma, compared to the conventional stent material of titanium (Ti). The results showed that a Mg extract inhibited proliferation and induced apoptosis in human cholangiocarcinoma cells, while a Mg plate inhibited cell adhesion and destroyed the cytoskeleton in the process of biodegradation. In animal experiments with H22 tumor-bearing mice, Mg wires implanted in tumors exhibited an inhibitory effect on their growth compared with Ti wires. Fifteen days after implantation of metal wires, the mean tumor volume and weight in the Mg group were significantly smaller than in the Ti group. We observed the dynamic-degradation process of Mg wires in tumors and generation of H2 gas via soft X-ray photography and scanning electron microscopy. Histopathological analyses showed that apoptosis of tumor cells around Mg wires significantly increased, expression of carbonic anhydrase 9 significantly decreased, and the upstream protein hypoxia-inducible factor 1-alpha also decreased to some extent. Taken together, these results indicated that biodegradable Mg had antitumor properties both in vitro and in vivo, suggesting its potential application as a novel material for biodegradable biliary stents.

One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy.

Construction of single component theranostic agent with one-for-all features to concurrently afford both multi-modality imaging and therapy is an appealing yet significantly challenging task. Herein, a type of luminogens with aggregation-induced emission (AIE) characteristics are tactfully designed and facilely synthesized. These AIE luminogens (AIEgens) exhibit long emission wavelengths, good photostability, remarkable biocompatibility, good reactive oxygen species (ROS) generation performance and excellent photothermal conversion efficiency, which allow them to be powerfully utilized for in vitro and in vivo cancer phototheranostics. The results show that one of the AIEgens is capable of precisely diagnosing solid tumors of mice by means of combined near-infrared-I/II (NIR-I/II) fluorescence-photoacoustic imaging, meanwhile this AIEgen can activate photodynamic and photothermal synergistic therapy (PDT-PTT) upon laser irradiation, resulting in excellent tumor elimination efficacy with only once injection and irradiation. This study thus provides a versatile platform for practical cancer theranostics.

NIR-II AIEgens: A Win-Win Integration towards Bioapplications.

Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed by penetration depth and fluorescence efficiency, offering high-performance imaging with enhanced precision. Some reported NIR-II AIEgens demonstrate capabilities for fluorescence and photoacoustic bimodal imaging, and fluorescence imaging guided photothermal therapy, which not only improves diagnosis accuracy but provides an efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting NIR-II AIEgens with regard to molecular design strategies and bioapplications, and puts forward current challenges and promising prospects. This timely sketch should benefit the further exploitation of diverse and multifunctional NIR-II AIEgens for a wide array of applications.

Lightweight Porous Polystyrene with High Thermal Conductivity by Constructing 3D Interconnected Network of Boron Nitride Nanosheets.

A composite foam consisting of foamed cross-linking polystyrene (c-PS) and boron nitride nanosheets (BNNSs) was synthesized, which shows a higher thermal conductivity (TC) than the corresponding solid counterparts. The BNNS fillers are found to be aligned along the cell wall as a result of the biaxial stress field from cell expansion during the formation of three-dimensional interconnectivity in the foams, resulting in an enhanced TC of 1.28 W/m K, nearly two and four times those of its solid counterpart and pure c-PS, respectively. It is found that the foaming-assisted formation of the filler network is an efficient strategy to improve the TC at low filler loadings in the composites. Furthermore, the composite foams exhibit low density, rather low dielectric constants and dissipation factors at wide frequency and temperature ranges. The present work provides a novel approach to design and prepare lightweight heat conductive polymers with low filler loadings as low-density heat management materials for potential applications in aeronautics and aerospace components.

An All-Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging-Guided Synergistic Therapy.

Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, the optimum use of dissipated energy through both radiative and nonradiative pathways is definitely appealing, yet a significantly challenging task. To the best of the knowledge, there have been no previous reports on a single molecular species effective at affording all phototheranostic modalities including fluorescence imaging (FLI), photoacoustic imaging (PAI), photothermal imaging (PTI), photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, a simple and highly powerful one-for-all phototheranostics based on aggregation-induced emission (AIE)-active fluorophores is tactfully designed and constructed. Thanks to its strong electron donor-acceptor interaction and finely modulated intramolecular motion, the AIE fluorophore-based nanoparticles simultaneously exhibit bright near-infrared II (NIR-II) fluorescence emission, efficient reactive oxygen species generation, and high photothermal conversion efficiency upon NIR irradiation, indicating the actualization of a balance between radiative and nonradiative energy dissipations. Furthermore, the unprecedented performance on NIR-II FLI-PAI-PTI trimodal-imaging-guided PDT-PTT synergistic therapy is demonstrated by the precise tumor diagnosis and complete tumor elimination outcomes. This study thus brings a new insight into the development of superior versatile phototheranostics for practical cancer theranostics.