Analysis of the mechanism of action of Euphorbia fischeriana Steud on cirrhosis based on network pharmacology.

This study aimed to employ network pharmacology to elucidate the mechanism by which Euphorbia fischeriana Steud (EFS) exhibits the efficacy on cirrhosis. The compounds and targets of EFS were retrieved from Traditional Chinese Medicine Integrated Database and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Next, these compounds and targets were analyzed based on protein-protein interaction (PPI) network. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling network was established based on KEGG database. We constructed a compound-compound target-intersection target-pathway PPI network, including 20 compounds, 19 intersection targets between compound targets and EFS targets. Among the 20 compounds, 8-Isopentenyl-kaempferol has the most targets, with 27 targets, followed by 3,4',5-Trihydroxy-7-methoxy-8-isopentenylflavone, Formononetin, Isoxanthohumol, and Isokurarinone with potential targets of 26, 22, 18, and 14, respectively. Top 5 targets are HSP90AA1, PTGS2, NOS2, MAPK14, and PPARG. KEGG pathway enrichment analysis showed that pathways such as Hepatitis B, Hepatitis C, Lipid and atherosclerosis, and AGE-RAGE signaling pathway in diabetic complications were closely related to the infection and abnormal metabolism of the liver. The application of network pharmacology could identify potential targets of EFS with a low false-positive rate and provide novel insight into the mechanism of action of EFS on cirrhosis.

Filtering for Switched T-S Fuzzy Systems With Persistent Dwell Time.

The H∞ filter design for a class of switched Takagi-Sugeno (T-S) fuzzy systems with persistent dwell time (PDT) is investigated in this paper. The considered switched fuzzy systems contain a limited number of subsystems and each local subsystem is represented by the well-known T-S fuzzy model. Compared with the dwell time (DT) switching or average DT switching that attracted quantities of interests over the last decade, the PDT switching considered in this paper is known to be more general. The stability and L 2 -gain analysis for switched systems with PDT switching are derived first, based on which a set of full-order H∞ filter is designed to guarantee the global uniform asymptotic stability with a prescribed nonweighted H∞ noise attenuation performance for the resulting filtering error system. Finally, the effectiveness of the provided method is illustrated with an example.