Digital marketing program design based on abnormal consumer behavior data classification and improved homomorphic encryption algorithm.

This article endeavors to delve into the conceptualization of a digital marketing framework grounded in consumer data and homomorphic encryption. The methodology entails employing GridSearch to harmonize and store the leaf nodes acquired post-training of the CatBoost model. These leaf node data subsequently serve as inputs for the radial basis function (RBF) layer, facilitating the mapping of leaf nodes into the hidden layer space. This sequential process culminates in the classification of user online consumption data within the output layer. Furthermore, an enhancement is introduced to the conventional homomorphic encryption algorithm, bolstering privacy preservation throughout the processing of consumption data. This augmentation broadens the applicability of homomorphic encryption to encompass rational numbers. The integration of the Chinese Remainder Theorem is instrumental in the decryption of consumption-related information. Empirical findings unveil the exceptional generalization performance of the amalgamated model, exemplifying an AUC (area under the curve) value of 0.66, a classification accuracy of 98.56% for online consumption data, and an F1-score of 98.41. The enhanced homomorphic encryption algorithm boasts attributes of stability, security, and efficiency, thus fortifying our proposed solution in facilitating companies' access to precise, real-time market insights. Consequently, this aids in the optimization of digital marketing strategies and enables pinpoint positioning within the target market.

MLL3 Inhibits Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Promotes Secretion of Inflammatory Factors by Activating CCL2 and the NF-κB Pathway.

Rheumatoid arthritis (RA) remains the most common inflammatory arthritis and a major cause of disability. This study investigated the mechanism of MLL3 in fibroblast-like synoviocyte (FLS) apoptosis and inflammatory factor secretion in RA. Expression of MLL3 in synovial tissue of RA patients and patients with bone trauma was detected. FLS was isolated and identified by flow cytometry. Expressions of TNF-α, IL-1ß, IL-8, and IL-10 and apoptosis were measured by MTT, flow cytometry, and ELISA. Western blot and qRT-PCR were performed to detect MLL3 and CCL2 expressions, H3K4me3 level, and NF-κB pathway-related proteins in rat joints. MLL3 was highly expressed in the synovial tissue of RA patients, and silencing MLL3 in FLS-RA promoted apoptosis, inhibited pro-inflammatory factors TNF-α, IL-1ß, and IL-8 secretion, and promoted anti-inflammatory factor IL-10 secretion. Inhibition of MLL3 suppressed intracellular H3K4me3 and CCL2 expressions. CCL2 activated the NF-κB pathway to promote pro-inflammatory factors TNF-α, IL-1ß, and IL-8, inhibit anti-inflammatory factor IL-10, and inhibit apoptosis in FLS-RA. Inhibition of MLL3 expression in RA rats reduced joint redness, swelling, and intra-articular inflammation, but increasing H3K4me3 level reversed the ameliorative effects of sh-MLL3 on RA rats. Collectively, MLL3 activated the NF-κB pathway by increasing H3K4me3 modification in the CCL2 promoter region in FLS-RA, thereby inhibiting apoptosis and promoting pro-inflammatory factors of FLS-RA.

Effectiveness of the medical student’s volunteer teaching in the training of the cardiopulmonary resuscitation among middle school students / 中国学校卫生

Objective@#To explore the effect of voluntary teaching for medical students on cardio-pulmonary resuscitation training for middle school students,and to provide a reference for education of first aid among primary and middle school students.@*Methods@#A total of 196 students from four classes in the first grade of a middle school were selected by convenient sampling method and divided into experimental group and control group according to the class. After the two groups of students were trained in unified theory, the students in the control group were trained by the medical staff in the hospital, and the students in the experimental group were trained by the volunteers of the medical students who had been strictly trained and assessed. After the training was finished, questionnaires were sent out to investigate the effect of training.@*Results@#Before the training, there was no significant difference in the theoretical scores between the two groups (t=1.18，P=0.24). After training, the theoretical and skill scores of the experimental group were(11.43±1.53)(5.68±1.80), that of the control group were(11.35±1.77)(5.30±1.76), and there was no significant difference between the experimental group and the control group(t=0.34，1.48，P>0.05).@*Conclusion@#The application of voluntary teaching in the training of middle school students’ cardiopulmonary resuscitation can improve the popularization rate of cardiopulmonary resuscitation, save medical resources effectively, and improve the practical ability of medical students.