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1.
Nat Prod Res ; 35(1): 167-173, 2021 Jan.
Article in English | MEDLINE | ID: mdl-31198051

ABSTRACT

Three previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus. Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P (2) showed somewhat inhibitory activity towards those tumor cells.


Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Juglandaceae/chemistry , Triterpenes/chemistry , Triterpenes/pharmacology , Antineoplastic Agents, Phytogenic/chemistry , Cell Line, Tumor , Drug Screening Assays, Antitumor , Glycosides/chemistry , HCT116 Cells , Hep G2 Cells , Humans , Magnetic Resonance Spectroscopy , Molecular Structure , Pancreatic Neoplasms/drug therapy , Pancreatic Neoplasms/pathology , Plant Leaves/chemistry , Dammaranes
2.
Bioorg Chem ; 95: 103493, 2020 01.
Article in English | MEDLINE | ID: mdl-31901753

ABSTRACT

Four new rarely occurred seco-dammarane triterpenoid glycosides (1-4) and four new dammarane triterpenoid glycosides (5-8), along with four known triterpenoids (9-12), were isolated from the 70% ethanol extract of the leaves of Cyclocarya paliurus (family Juglandaceae). Their structures were elucidated by extensive spectroscopic methods, including 1D/2D NMR and HRESIMS data, together with chemical analysis and DFT GIAO 13C NMR calculation. In bioassay, compounds 5-8 significantly increased glucose consumption in 3T3-L1 adipocytes, which could be the bioactive constituents for the anti-diabetes effect of the traditional usage of C. paliurus.


Subject(s)
Adipocytes/drug effects , Glycosides/pharmacology , Hypoglycemic Agents/pharmacology , Juglandaceae/chemistry , Triterpenes/pharmacology , 3T3-L1 Cells , Adipocytes/metabolism , Animals , Dose-Response Relationship, Drug , Glucose/metabolism , Glycosides/chemistry , Glycosides/isolation & purification , Hypoglycemic Agents/chemistry , Hypoglycemic Agents/isolation & purification , Mice , Molecular Structure , Plant Leaves/chemistry , Structure-Activity Relationship , Triterpenes/chemistry , Triterpenes/isolation & purification
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