ABSTRACT
OBJECTIVE: To explore the influence of caloric restriction combined with psychotherapy and chemotherapy associated by hybaroxia on the prognosis of patients with intracranial glioblastoma multiforme. METHODS: This was a perspective, nonrandom, no-double-blinded controlled study. All patients underwent total resection during November 2007 to April 2009 at Beijing Tiantan Hospital and Beijing Tiantan Puhua Hospital. All diagnoses were confirmed by molecule pathology. While 23 patients in control group underwent resections and radiochemotherapy, 11 patients in experimental group were further treated by caloric restriction plus psychotherapy and chemotherapy-associated hybaroxia. The life spans were compared between two groups. RESULTS: The mean survival time of patients in experimental group was (38 ± 13) months versus (20 ± 12) months in control group. The survival time of patients in experimental group was significantly longer than that in control group (P < 0.05). CONCLUSION: Caloric restriction plus psychotherapy and chemotherapy-associated hybaroxia can apparently prolong the life span of patients with glioblastoma multiforme.
