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OBJECTIVE: To study the polymorphism of angiotensin-type 1 receptor (AT1R) gene A1166C in familial primary hypertension and its distribution in Han Yellow race of China. METHODS: One hundred and four hypertensive patients with no family history, 178 hypertensive patients with familial history, and 150 healthy adults were randomly selected to participate in a prospective clinical trial, and genetype detection by standard polymerase chain reaction methods and restriction fragment length polymorphism (PCR-RFLP) in trials. The study was carried out between October 2009 and November 2010 at Jinan Center for Cardiovascular Disease, Affiliated Hospital of Taishan Medical College, Jinan, China. RESULTS: Notable statistical significances exist in the frequency of genotype and allele of A1166C in familial hypertension group (x2=7.663, p=0.020) compared with the normal control group (x2= 8.288, p=0.004). No significant difference was found in the hypertension group (x2 = 2.186, p=0.322) compared with the normal control group (x2=1.289, p=0.256) in the frequency of genotype and allele of A1166C. No significant differences were found between various ages or genders in each of the 3 groups in genotype and allele of A1166C (p>0.05) distribution. CONCLUSION: In the Han Yellow race population of China, the frequency of genotype and allele of A1166C of patients with familial hypertension is higher than that of healthy adults. The distribution of AT1R gene polymorphisms of A1166C is not related to age or gender.
Subject(s)
Ethnicity/genetics , Hypertension/genetics , Polymorphism, Genetic , Receptor, Angiotensin, Type 1/genetics , Aged , Alleles , China , Female , Genotype , Humans , Male , Middle AgedABSTRACT
Objective To investigate the relationship between resting heart rate (RHR) and target organs damage (TOD) in senile metabolic syndrome(SMS). Methods With case-control study,215 elderly patients with MS were divided into 3 groups according to the level of RHR [RHR1 group: RHR <70 beats/ minute (bpm) (n=55);RHR2group: 70 bpm ≤RHR<80 bpm [n=87);RHR3 group: RHR≥80 bpm (n=73).Mean-while ,60 healthy senile persons were taken as normal control group. For all objects researched, electrocardiography, echocardiography,carotid ultrasonography, creatinine clearance rate (Ccr) and quantitative assay for 24 hours' urina-ry microalbuminuria (MAU) were performed. Part of SMS patients was examined by coronary angiography and com-puter tomography (CT) of head. Results ① Compared with normal control group, RHR groups showed higher lev-els of carotid intima-medial thickness (IMT), carotid arterial diameter (CAD), left ventricular mass index (LVMI) and MAU, lower levels of left ventricular ejection fraction (LVEF) and Ccr (P<0.05 or 0.01). With RHR increas-ing among RHR groups,IMT,CAD,LVMI,MAU and the score of coronary artery stenosis increased,and LVEF and Cer decreased (P<0.05 or 0.01). ② The levels of IMT, CAD, LVMI and MAU were positively correlated to RHR (r=0.34,0.25,0.62, and 0.57, respectively, P<0.05 or 0.01). However, the levels of LVEF and Ccr were nega-tively correlated to RHR (r=-0.60,-0.52 respectively,P<0.01). ③ Logistic multivariate analysis showed that RHR, pulse pressure (PP), systolic blood pressure (SBP) and diastolic blood pressure (DBP) influenced TOD,such as myocardial hypertrophy,coronary heart disease,heart failure, cerebral stroke and renal damage in dif-ferent degrees, among them, PP and RHR played more important roles than those of other factors. Conclusion RHR may be an independent risk factors of TOD in senile MS. It is indicated that RHR regulation is important for the de-velopment of senile MS.
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0.05 ).An excellent correlation exists between the two methods (Y= 0.99 X- 0.01 ,r= 0.97 ,P
