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1.
Health Commun ; 38(4): 803-812, 2023 04.
Article in English | MEDLINE | ID: mdl-34555992

ABSTRACT

The Internet plays a crucial role for people searching for health information. In the context of parents faced with a prenatal diagnosis of a chromosomal abnormality, Internet-based resources convey critical information and attitudes that bear on the process of healthcare decision-making. In this study, we collected and analyzed 268 websites for Klinefelter syndrome and Down syndrome, which are two of the most common genetic conditions marked by an abnormal number of chromosomes. While these two syndromes are quite different in terms of their associated symptoms and health consequences, they are commonly screened for, have similar incidence rates, and parents who are presented with prenatal diagnosis of the two conditions terminate pregnancies at similar rates. The study found substantial differences in framings of information, and social support available online for Klinefelter syndrome and Down syndrome. This study's key finding supports the argument that social support and framing are important mechanisms that mediate online information and perceptions of information utility, hope and decision tendency. The study extends theories and literature related to information framing in a mass media context, social support, and cognitive information processing and applies to investigating online health information, social support and perceptions.


Subject(s)
Down Syndrome , Klinefelter Syndrome , Pregnancy , Female , Humans , Down Syndrome/diagnosis , Down Syndrome/genetics , Klinefelter Syndrome/diagnosis , Klinefelter Syndrome/genetics , Prenatal Diagnosis/psychology , Social Support
2.
Radiat Oncol ; 7: 8, 2012 Jan 25.
Article in English | MEDLINE | ID: mdl-22277577

ABSTRACT

131I-MIBG therapy for neuroendocrine tumours may be dose limited. The common range of applied cumulative activities is 10-40 GBq. We report the uneventful cumulative administration of 111 GBq (= 3 Ci) 131I-MIBG in a patient with metastatic paraganglioma. Ten courses of 131I-MIBG therapy were given within six years, accomplishing symptomatic, hormonal and tumour responses with no serious adverse effects. Chemotherapy with cisplatin/vinblastine/dacarbazine was the final treatment modality with temporary control of disease, but eventually the patient died of progression. The observed cumulative activity of 131I-MIBG represents the highest value reported to our knowledge, and even though 12.6 GBq of 90Y-DOTATOC were added intermediately, no associated relevant bone marrow, hepatic or other toxicity were observed. In an individual attempt to palliate metastatic disease high cumulative activity alone should not preclude the patient from repeat treatment.


Subject(s)
3-Iodobenzylguanidine/therapeutic use , Iodine Radioisotopes/therapeutic use , Paraganglioma/radiotherapy , Radiopharmaceuticals/therapeutic use , Retroperitoneal Neoplasms/radiotherapy , Humans , Paraganglioma/secondary , Retroperitoneal Neoplasms/pathology , Treatment Outcome
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