ABSTRACT
Se presenta un caso de un lipoma localizado en el dorso de la lengua, de una paciente de sexo femenino, de 8 años de edad. El lipoma es una neoplasia benigna que, a nivel general, se presenta más frecuentemente en mujeres adultas, mayores de cuarenta años. Se caracteriza por ser una tumoración de crecimiento lento, indolora, amarillenta y de superficie lisa. Rar vez se observa en la cavidad oral y, cuando existe su ubicación preferencial es una mucosa yugal y fondo del vestíbulo. Nos parece interesante presentar este caso por lo atípico de su prensentación etárea y ubicación anatómica, además, se anexa una revisión que considera aspectos epidemiológica y características clínicas e histológicas
Subject(s)
Humans , Female , Lipoma , Tongue Neoplasms , Lipectomy , Lipoma , Prognosis , Tongue NeoplasmsABSTRACT
Chronic sclerosing unspecific sialadenitis or KYttner tumor, is an infrequent inflammatory lesion of submandibular gland. We report a 60 years old male presenting with a slowly growing, painless, bilateral submandibular tumor of two years of evolution. Pathological examinations showed marked atrophy of glandular parenchyma with increased fibrous connective tissue and an intense lymphocytic infiltration with lymphoid follicle formation. Lymphocyte population study with kappa, lambda, CD20 and CD45RO antibodies was similar to that observed in reactive lymph nodes. There was no over expression of Bcl-2 gene protein, involved in the phenomenon of apoptosis of glandular tissue, that could explain the pathogenesis of atrophy. This protein was positive only in lymphoid cells and glandular conducts. An immune etiology, with replacement of glandular tissue by lymphoid and fibrous connective tissue is suggested
Subject(s)
Humans , Male , Middle Aged , Sialadenitis/diagnosis , Submandibular Gland Neoplasms/diagnosis , Submandibular Gland Neoplasms/surgery , Lymphocytes, Tumor-Infiltrating , Salivary Glands/ultrastructure , ImmunohistochemistryABSTRACT
Background: Salivary gland tumors have heterogeneous pathological features. Oncogene Bcl-2 product expression inhibits apoptosis and therefore is important for tumor proliferation. Aim: To assess the immunohistochemical gene Bcl-2 protein expression in salivary gland tumors. Material and methods: Twenty seven salivary gland tumors were selected from the archives of the Pathology Department of Temuco Regional Hospital. There were 20 pleiomorphic adenomas, 4 cystic adenoid carcinomas and three mucoepidermoid carcinomas. Immunohistochemical gene Bcl-2 protein expression was determined in paraffin included pathological slices. Results: All pleiomorphic adenomas expressed the protein, specially in tubulo ductal structures, solid and trabecular areas. All cystic adenoid carcinomas expressed the protein in myoepithelial cells. Two mucoepidermoid carcinomas were positive, only in the epidermoid areas. Conclusions: immunohistochemical gene Bcl-2 protein was expressed in virtually all benign and malignant salivary gland tumors. This observation suggest an important role of this protein in the development of these tumors
Subject(s)
Humans , Female , Male , Middle Aged , Salivary Gland Neoplasms/genetics , Proto-Oncogene Proteins c-bcl-2/analysis , Gene Expression , Parotid Neoplasms , Salivary Gland Neoplasms/diagnosis , Adenoma, Pleomorphic/genetics , Immunohistochemistry/methods , Biomarkers, Tumor , Gene Expression RegulationABSTRACT
Background: DNA content determination is a useful tool in the characterization of different malignant tumors. Aim: to measure DNA content in cells of salivary gland tumors as adjunct to histological diagnosis, correlatting morphologic and biological features of these tumors. Material and methods: from the archives of the pathology service of a general hospital, 21 salivary gland tumors, 15 pleomorphic adenomas, 3 mucoepidermoid carcinomas and 3 cystic adenoid carcinomas were seleced. DNA content was determined in the histological samples using a flow cytometric DNA analysis. Results: all pleomorphic adenomas had a normal or diploid DNA content. Fifty percent of malignant tumors had an aneuploid DNA content (1 mucoepidermoid carcinoma and 2 cystic adenoid carcinomas). Conclusions: DNA determination may help in the histological diagnosis of salivary gland tumors. The presence of aneuploidy suggests malignity
