ABSTRACT
A review of the literature on parasitology, which we did not have the opportunity to get acquainted with during the Japanese occupation but which was made accessible to us after liberation, has disclosed a number of interesting facts and additional knowledge which are here presented for whatever benefit may be derived by the medical practitioners, medical students, and scientific investigators in this country. It includes new knowledge on: (1) the treatment of clinical malaria with bigger doses of atabrine-28 to 42 tablets of 0.10 Gm. for one course of 8 days instead of only 15 tablets in 5 days for adults; (2) the definite preference of the American forces for atabrine over quinine in both suppressive and clinical treatments of malaria; (3) the negative action of the wonder drug penicillin against induced or inoculation malaria in man; (4) the good effect of tyrothricin, another antibiotic, in experimental Plasmodium gallinaceum infection in chickens when given intravenously; (5) the most recently announced drugs such as Paludrine and SN 7618 against malaria: (6) the use of newer sulfonamides like sulfadiazine and sulfapyrazine in the eradication of the exo-erythrocytic stages of Plasmodium gallinaceum and the failure of the same drug against the same stages of Plasmodium elongatum; (7) the present status of immunity in malaria and its mechanism of production supporting the combined operation of the phagocytic and humoral theories; (8) the more recent attempt at active immunization of ducklings from Plasmodium lophurae infection with the use of plasmodial residues mixed with Staphylococcus toxoid, which may pave the way for the elaboration of a vaccine against human malaria; (9) the exo-erythrocytic cycle in malaria, with special emphasis on its present status as applied to the human species; (10) the use of DDT, the wonder insecticide of World War II in malaria control; (11) the new acid-ether technic of fecal examination for Schistosoma japonicum eggs; (12) the effectiveness of one part per million (1 P.P.M.) residual chlorine against Schistosoma japonicum cercariae when applied to infected waters; (13) the early manifestations of filariasis bancrofti and the use of the intra-dermal test for early diagnosis; (14) the improvement suggested in enhancing the positive diagnosis of amoebiasis by fixation of fecal smears at the bedside and the permanent staining afterwards of the same in the laboratory; (15) the present status of complement-fixation test in the diagnosis of amoebiasis; (16) the use of diodoquin as an anti-amoebic drug; (17) a report of vaginitis of amoebic etiology; (18) the possible pathogenicity of Dientamoeba fragilis; (19) some unusual radislogical findings in giardiasis which may prove confusing at times in the diagnosis of peptic ulcer; and(20) the previously unrecognized disease entity of man called human toxoplasmosis. (Summary)
ABSTRACT
1. Quinacrine hydrochloride with sodium bicarbonate when given orally to 16 patients with taeniasis produced expulsion of the worm in 15 or a cure rate of 93.7 per cent. Worms were expelled alive and stained with deep yellow color of quinacrine2. Out of 15 cases of taeniasis successfully treated 2 were caused by Taenia solium and 13 by Taenia saginata3. There was one case of multiple infection by Taenia saginata which is the first and only case so far recorded in the department of parasitology4. The symptoms experienced by some patients were nausea, vomitting, hunger pains and general body weakness which were considered benign and hence hospitalization during treatment is not warranted. (Summary)
ABSTRACT
The ideal chemotherapeutic agent for paragonimiasis, aside from being free from adverse effects on the host, should consistently kill all adults wherever these are lodged in the body of the host. No agent presently known closely approaches this ideal. As far as we can gather from the literature available to us, only emetine is accepted to have a definite specific value in the treatment of paragonimus infection in man and in experimentasl animals. (Author)
ABSTRACT
Experimental evidences obtained from the very limited number of cats used in this study suggest that cutting off the pulmonary venous circulation to one lung in the cat may affect the localization and the growth of Paragonimus in the affected lung. Fewer worms may be found in the lung with a ligated pulmonary artery, and the worms that do localize in that lung may not grow as well as in the lung with an intact pulmonary artery. The integrity of the venous circulation to the lungs through the pulmonary artery may therefore be necessary for the normal localization and growth of Paragonimus in the lungs. Further experiments to obtain decisive results are indicated. (Conclusions)
