Development of a three-dimensional dose evaluation method for computed tomography.

During a single scan using computed tomography, an X-ray tube orbits along a 360°-circular path around the patient. A scan obtained using the half-cylindrical type phantoms with a radiochromic film sandwiched in between reveals a pixel value map illustrating the two-dimensional (2D) dose distribution. A three-dimensional (3D) dose distribution can be obtained with a 360° rotation of the 2D dose map. This study evaluates the concept and methodology of creating a 3D dose map to develop a phantom with a radiochromic film for obtaining the 3D dose distribution. The coronal and axial plane dose distributions were also evaluated. A single scan computed tomography image obtained using a half-cylindrical type of acrylic phantom with a sandwiched radiochromic film was studied. The diameters of the phantoms were 10 and 16 cm, and their lengths were 30 cm. A 2D image of the XR-QA2 film was obtained using an image scanner and image processing software. A red channel image was used to obtain the 3D dose distribution using a computing platform. A pseudo color was applied to the red channel image from which cross-sectional color images were obtained. Half of the cross-sectional pixel data were rotated by 360° to generate the data for each axial plane. The image created was saved, and a 3D pixel value map was constructed. The dose measurement procedure for the 3D dose distribution was developed using half-cylindrical acrylic phantoms with a radiochromic film.

USE OF ULTRAVIOLET RAY PRE-IRRADIATION TO IMPROVE THE ACCURACY OF LOW-DOSE MEASUREMENTS OF THE CT USING A GAFCHROMIC RTQA2 FILM.

The purpose of this study is to develop a method for use at extremely low-dose ranges and to decrease the uncertainty outside the recommended range of Gafchromic RTQA2 (RTQA2). By this method, the CT dose including the scattered radiation region can be grasped. The base density was increased by ultraviolet (UV)-ray preirradiation. RTQA2 was irradiated with UV-A rays for 26 and 40 h. Subsequently, RTQA2 was exposed to 2, 4, 6, 8, 10, 25, 50, 75, 100, 150, 200 and 250 mGy X-rays using a segmentation method. Calibration curves with and without UV-A irradiation were compared. The calibration curve with 40-h UV-A ray irradiation was the most linear, and a steeper slope area was not observed. The uncertainty in the calibration curve was reduced (p < 0.05). UV-A ray irradiation is an effective method for treating RTQA2; the accuracy in the extremely low-dose range of RTQA2 was improved.

Intensities of Incident and Transmitted Ultraviolet-A Rays through Gafchromic Films.

Gafchromic films have been applied to X-ray dosimetry in diagnostic radiology. To correct nonuniformity errors in Gafchromic films, X-rays in the double-exposure technique can be replaced with ultraviolet (UV)-A rays. Intensities of the incident and transmitted UV-A rays were measured. However, it is unclear whether the chemical color change of Gafchromic films affects the UV-A transmission intensity. Gafchromic EBT3 films were suitable to be used in this study because non-UV protection layers are present on both sides of the film. The film is placed between UV-A ray light-emitting diodes and a probe of a UV meter. Gafchromic EBT3 films were irradiated by UV-A rays for up to 60 min. Data for analysis were obtained in the subsequent 60 min. Images from before and after UV-A irradiation were subtracted. When using 375 nm UV-A, the mean ± standard deviation (SD) of the pixel values in the subtracted image was remarkably high (11,194.15 ± 586.63). However, the UV-A transmissivity remained constant throughout the 60 min irradiation period. The mean ± SD UV-A transmission intensity was 184.48 ± 0.50 µm/cm2. Our findings demonstrate that color density changes in Gafchromic EBT3 films do not affect their UV-A transmission. Therefore, Gafchromic films were irradiated by UV-A rays as a preexposure.

Correction of nonuniformity error of Gafchromic EBT2 and EBT3.

This study investigates an X-ray dose measurement method for computed tomography using Gafchromic films. Nonuniformity of the active layer is a major problem in Gafchromic films. In radiotherapy, nonuniformity error is reduced by applying the double-exposure technique, but this is impractical in diagnostic radiology because of the heel effect. Therefore, we propose replacing the X-rays in the double-exposure technique with ultraviolet (UV)-A irradiation of Gafchromic EBT2 and EBT3. To improve the reproducibility of the scan position, Gafchromic EBT2 and EBT3 films were attached to a 3-mm-thick acrylic plate. The samples were then irradiated with a 10 W UV-A fluorescent lamp placed at a distance of 72cm for 30, 60, and 90 minutes. The profile curves were evaluated along the long and short axes of the film center, and the standard deviations of the pixel values were calculated over large areas of the films. Paired t-test was performed. UV-A irradiation exerted a significant effect on Gafchromic EBT2 (paired t-test; p = 0.0275) but not on EBT3 (paired t-test; p = 0.2785). Similarly, the homogeneity was improved in Gafchromic EBT2 but not in EBT3. Therefore, the double-exposure technique under UV-A irradiation is suitable only for EBT2 films.

Ultraviolet exposure of Gafchromic XR-RV3 and XR-SP2 films.

Gafchromic film has been used for X-ray dose measurement in diagnostic examinations. Their use has been initiated for three-dimensional X-ray dose measurement by using the high-resolution characteristics of Gafchromic films in computed tomography. However, it is necessary to solve the problem of nonuniform thickness in the active layers of Gafchromic films. A double exposure technique using X-rays is performed in therapeutic radiology; it is difficult to use in a diagnostic examination because of the heel effect. Therefore, it is suggested that ultraviolet (UV) rays be substituted for X-rays. However, the appropriate UV wavelength is unknown. In this study, we aimed to determine which UV wavelengths are effective to expose Gafchromic XR-RV3 and XR-SP2. UV lamps with peak wavelengths of 245 nm, 310 nm, and 365 nm were used. The three UV wavelengths were used to irradiate Gafchromic XR-RV3 and XR-SP2 films for 60 min, and irradiation was repeated every 60 min for 600 min thereafter. Films were scanned after each irradiation period on a flatbed scanner. The images were split into their red-green-blue components, and red images were stored using ImageJ version 1.44o image analysis software. Regions of interest (ROI), 0.5 inches in diameter, were placed at the centers of the subtracted Gafchromic film images, and graphs of UV irradiation duration and mean pixel values were plotted. There were reactions to UV-A on both Gafchromic XR-RV3 and XR-SP2; those to UV-B were moderate. However, UV-C demonstrated few reactions with Gafchromic XR-RV3 and XR-SP2. From these results, irradiation with UV-A may be able to correct nonuniformity errors. Uniform UV-A irradiation of Gafchromic films with large areas is possible, and UV rays can be used as a substitute for X-rays in the double exposure technique.

Comparing three UV wavelengths for pre-exposing Gafchromic EBT2 and EBT3 films.

Gafchromic films are used for X-ray dose measurements during diagnostic examinations and have begun to be used for three-dimensional X-ray dose measurements using the high-resolution characteristics of Gafchromic films for computed tomography. However, the problem of unevenness in Gafchromic film active layers needs to be resolved. Double exposures using X-rays are performed during therapeutic radiology, although this is difficult for a diagnostic examination because of a heel effect. Thus, it has been suggested that ultraviolet (UV) radiation be used as a substitute for X-rays. However, the appropriate UV wavelength has not been determined. Thus, we conducted this study to decide an appropriate UV wavelength. UV peak wavelengths of 245 nm (UV-A), 310 nm (UV-B), and 365 nm (UV-C) were used to irradiate EBT2 and EBT3 films. Each UV wavelength was irradiated for 5, 15, 30, and 60 min, and irradiation was then repeated every 60 min up to 360 min. Gafchromic films were scanned after every irradiation using a flatbed scanner. Images were split into RGB images, and red images were analyzed using ImageJ, version 1.44, image analysis software. A region of interest (ROI) one-half inch in diameter was placed in the center of subtracted Gafchromic film images, and UV irradiation times were plotted against mean pixel values. There were reactions in the front and back of Gafchromic EBT3 and the back of Gafchromic EBT2 with UV-A and UV-B. However, UV-C resulted in some reactions in both sides of Gafchromic EBT2 and EBT3. The UV-A and UV-B wavelengths should be used.