ABSTRACT
The present study was done to investigate the effect of vaginal distention of the uterine myoelectrical activity of nonpregnant and nonlactating female dogs under general anesthesia in a trial to clarify the contradiction reported and to establish the nature of response. It was found that vaginal inflation increased the frequency and amplitude of the uterine basal electrical rhythm significantly (P less than 0.05). Moreover, the enhancement of the myometrial electrical activity recorded in this work was found to occur instantaneously with vaginal inflation (within 3.6 +/- 0.39 s) and decreased rapidly (within seconds) after vaginal deflation. This response was found to be reproducible. However, the excessive repetition of inflation was found to delay the occurrence of change and reduce the response proportionally. Our finding could be regarded as experimental evidence for the existence of a vagino-uterine reflex, in which nervous signals originating in the vagina as a result of stimulation of vaginal stretch receptors by vaginal distention produce a spinal reflex enhancement of the uterine activity. This reflex was abolished by atropinization.
Subject(s)
Mechanoreceptors/physiology , Reflex/physiology , Uterine Contraction/physiology , Vagina/innervation , Animals , Dogs , Electromyography , Female , Physical Stimulation , Pregnancy , Uterus/innervationSubject(s)
Copper , Intrauterine Devices , Menorrhagia , Menstruation , Chemical Phenomena , Chemistry , Contraception , Disease , Egypt , Family Planning Services , Inorganic Chemicals , Menstruation Disturbances , Metals , Reproduction , UterusABSTRACT
The effect of marital status, age, parity, age at menarche, maternal size, arterial blood pressure, position and size of the uterus and hematologic parameters on the magnitude of menstrual blood loss was investigated in 745 randomly selected women in normal physiologic condition, aged 14-49 years, from a city population (Cairo). Menstrual blood loss was found to be related to parity, weight and body surface area and systolic and pulse pressure and to depend mainly upon the hematologic indices reflecting the state of iron balance and anemia in the body.
Subject(s)
Blood , Menstruation , Adolescent , Adult , Age Factors , Blood Pressure , Body Height , Body Surface Area , Body Weight , Egypt , Female , Hematology , Humans , Marriage , Menarche , Middle Aged , Pulse , Uterus/anatomy & histologyABSTRACT
Two physiologic studies of menstrual blood loss in Egyptian women are presented below. In the first, an attempt was made to establish the normal range of menstrual blood loss of Egyptian women, to test their individual consistency in the amount of menstrual blood loss and to determine the iron requirements needed to compensate for iron loss and prevent iron deficiency anemia in menstruating Egyptian women. In the second, physiologic and other variables affecting the magnitude of menstrual blood loss in Egyptian women were investigated.
Subject(s)
Blood , Menstruation , Adolescent , Adult , Anemia, Hypochromic/prevention & control , Egypt , Female , Humans , Iron/blood , Middle Aged , Nutritional Requirements , Reference Values , Spectrophotometry, AtomicABSTRACT
In an attempt to find an IUD that will cause a minimum amount of blood loss, while continuing to be effective and easily retained, we are studying 4 medicated IUDs: a copper-bearing Lipps Loop, a Copper-T-200, a progesterone-releasing U-coil, and a tranexamic-acid-releasing Lippes Loop. Inert devices of the same shape and size are used as controls. This is a comparison of the findings on menstrual blood loss and loss and changes in bleeding patterns for patients using the plain and copper-bearing Lippes Loops. Preliminary results for the progesterone-bearing U-coil and the tranexamic-acid-releasing Lippes Loop are also given, but studies of these devices are not yet complete.
