Diagnostic and Therapeutic Challenges in Ocular Histoplasmosis - A Case Report.

Purpose: To report a rare case of skin biopsy proven Histoplasma panuveitis.Method: Observational case report of a 76-year-old Asian Indian man presented as panuveitis. Clinical course, diagnostic and treatment difficulties and confocal microscopy findings were studied.Result: Patient presented with mild anterior uveitis, membranous vitritis and large chorio-retinal lesions in peripheral fundus with a small macular scar in the right eye. Positive quantiferon test along with chest and adrenal findings initially misled ophthalmologist and pulmonologist to commence anti-tubercular treatment with steroids which further worsened the inflammation and the fungus involved iris and scleral tissue. Skin biopsy from the lesions on thigh revealed histoplasma spores and confocal microscopy showed similar cystic lesions on endothelium. Prolonged course of anti-fungal with steroids resulted in resolution of the infection.Conclusion: Histoplasma uveitis can worsen with steroids only treatment and may invade iris and scleral tissue which may require prolonged treatment with antifungal agents.

Neurocysticercosis in Children with Seizures: A Cross-Sectional Study.

BACKGROUND: Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. There is a lack of data on the prevalence of NCC and its clinical characteristics among those with seizure in South-Western Nepal. AIMS AND OBJECTIVES: To study the prevalence and clinical characteristics of NCC in children with seizures. MATERIAL AND METHODS: All children admitted to Universal College of Medical Sciences, a tertiary hospital in South-Western Nepal with seizures during 2014-16, were tested for NCC. NCC was diagnosed by neuroimaging [computerized tomography (CT) scan or magnetic resonance imaging (MRI)]. We used logistic regression to test the association between NCC with participants' characteristics and clinical symptoms. RESULTS: Among 4962 in-patient children, 168 (104 boys and 64 girls) had seizures (138 with generalized tonic clonic seizures (GTCS) and 30 with focal seizures). 43% of children with seizures had CT scan confirmed NCC. The prevalence of NCC in the oldest children (13-16 years) was significantly greater (57.1% versus 15.6%) compared to the youngest (0-4 years) one (p < 0.001). Among 72 children with NCC, the proportions of children with vesicular, calcified, and colloidal stages were 76% (n = 35), 18% (n = 13), and 6% (n = 2), respectively. Children with focal seizures had 13% more NCC compared to those with GTCS but the result was statistically not significant. The adjusted odds of having NCC among 5-8 years, 9-12 years, and 13-16 years children were 6.6 (1.78-24.60), 11.06 (2.74-44.60), and 14.47 (3.13-66.96), respectively, compared to 0-4-year-old children. Reoccurrence of seizures within the first 3 months of taking antiepileptic drug in those with NCC was approximately 3 times higher compared to those without NCC (11% versus 4%, p = 0.084). CONCLUSIONS: This study shows that NCC contributes significantly to higher prevalence of seizures in children in South-Western region of Nepal.